Ubiquitination, an important type of protein posttranslational modification (PTM), plays a
crucial role in controlling substrate degradation and subsequently mediates the “quantity” …

Alterations in protein ubiquitylation and hypoxia are commonly associated with cancer.
Ubiquitylation is carried out by three sequentially acting ubiquitylating enzymes and can be …

While hypoxia promotes carcinogenesis, tumour aggressiveness, metastasis, and resistance
to oncological treatments, the impacts of hyperoxia on tumours are rarely explored because …

Abstract Hypoxia-inducible factor-1 (HIF-1) is a transcription factor that acts as a regulator of
oxygen (O2) homeostasis in metazoan species by binding to hypoxia response elements …

Hypoxia exerts a profound impact on diverse aspects of cancer biology. Increasing evidence
has revealed novel functions of hypoxia in cancer cell epigenomics, epitranscriptomics …

Aging is a major risk factor for most chronic disorders, for which cellular senescence is one
of the central hallmarks. Senescent cells develop the pro‐inflammatory senescence …

Hypoxia is known to be commonly present in breast tumor microenvironments. Stem-like
cells that repopulate breast tumors, termed tumor-repopulating cells (TRC), thrive under …

Neurodegenerative diseases (NDs) are characteristic with progression of neuron
degeneration, resulting in dysfunction of cognition and mobility. Many neurodegenerative …

Faithful eucaryotic cell division requires spatio-temporal orchestration of multiple sequential
events. To ensure the dynamic nature of these molecular and morphological transitions, a …

Alterations in protein ubiquitination and hypoxia-inducible factor (HIF) signaling both
contribute to tumorigenesis and tumor progression. Ubiquitination is a dynamic process that …