Current strategies for brain drug delivery

X Dong - Theranostics, 2018 - pmc.ncbi.nlm.nih.gov
The blood-brain barrier (BBB) has been a great hurdle for brain drug delivery. The BBB in
healthy brain is a diffusion barrier essential for protecting normal brain function by impeding …

Designing delivery systems for functional ingredients by protein/polysaccharide interactions

H Li, T Wang, Y Hu, J Wu, P Van der Meeren - Trends in Food Science & …, 2022 - Elsevier
Background Designing delivery systems (or called encapsulation systems) for functional
ingredients recently has received growing interest in the food industry, which aims to …

Drug delivery to the brain across the blood–brain barrier using nanomaterials

YH Tsou, XQ Zhang, H Zhu, S Syed, X Xu - Small, 2017 - Wiley Online Library
A major obstacle facing brain diseases such as Alzheimer's disease, multiple sclerosis,
brain tumors, and strokes is the blood–brain barrier (BBB). The BBB prevents the passage of …

Effective and targeted human orthotopic glioblastoma xenograft therapy via a multifunctional biomimetic nanomedicine

Y Zou, Y Liu, Z Yang, D Zhang, Y Lu… - Advanced …, 2018 - Wiley Online Library
Glioblastoma multiforme (GBM) is a fatal central nervous system tumor without effective
treatment. Chemotherapeutic agents are mainstays in the treatment of glioblastoma …

[HTML][HTML] Bio-based and bio-inspired adhesives from animals and plants for biomedical applications

TM Lutz, C Kimna, A Casini, O Lieleg - Materials Today Bio, 2022 - Elsevier
With the “many-headed” slime mold Physarum polycelphalum having been voted the
unicellular organism of the year 2021 by the German Society of Protozoology, we are …

Strategies facilitating the permeation of nanoparticles through blood-brain barrier: An insight towards the development of brain-targeted drug delivery system

A Mishra, R Kumar, J Mishra, K Dutta, P Ahlawat… - Journal of Drug Delivery …, 2023 - Elsevier
The blood-brain barrier (BBB) is a membrane barrier considered one of the most crucial
protective architectures in the central nervous system (CNS). Its presence acts as a hurdle …

Targeting the blood-brain barrier for the delivery of stroke therapies

A D'Souza, KM Dave, RA Stetler… - Advanced drug delivery …, 2021 - Elsevier
A variety of neuroprotectants have shown promise in treating ischemic stroke, yet their
delivery to the brain remains a challenge. The endothelial cells lining the blood-brain barrier …

[HTML][HTML] Challenges and opportunities for improving the druggability of natural product: Why need drug delivery system?

P Tang, T Shen, H Wang, R Zhang, X Zhang… - Biomedicine & …, 2023 - Elsevier
Bioactive natural products (BNPs) are the marrow of medicinal plants, which are the
secondary metabolites of organisms and have been the most famous drug discovery …

Ozone-induced neurotoxicity: In vitro and in vivo evidence

A Singh, S Suresh, C Vellapandian - Ageing Research Reviews, 2023 - Elsevier
Together with cities in higher-income nations, it is anticipated that the real global ozone is
rising in densely populated areas of Asia and Africa. This review aims to discuss the …

Carbohydrate‐based nanomaterials for biomedical applications

S Gim, Y Zhu, PH Seeberger… - Wiley Interdisciplinary …, 2019 - Wiley Online Library
Carbohydrates are abundant biomolecules, with a strong tendency to form supramolecular
networks. A host of carbohydrate‐based nanomaterials have been exploited for biomedical …