Stroke is the most prevalent cardiovascular disease worldwide, and is still one of the leading
causes of death and disability. Stem cell-based therapy is actively being investigated as a …

The excessive extracellular accumulation of glutamate in the ischemic brain leads to an
overactivation of glutamate receptors with consequent excitotoxic neuronal death. Neuronal …

Cranial radiotherapy, although beneficial for the treatment of brain tumors, inevitably leads
to normal tissue damage that can induce unintended neurocognitive complications that are …

Hippocampal neuron death is a key factor in vascular dementia (VD) induced by chronic
cerebral hypoperfusion (CCH). Dl-3-n-butylphthalide (NBP) is a multiple-effects drug …

The purpose of the current study was to investigate whether peptidyl-prolyl cis/trans
isomerase NIMA-interacting 1 (Pin1) can interact with calpastatin (CAST) and regulate …

Downregulation of GABAergic synaptic transmission contributes to the increase in overall
excitatory activity in the ischemic brain. A reduction of GABA A receptor (GABA AR) surface …

This protocol aims at standardizing the procedure to obtain primary cultures of hippocampal
and cerebrocortical neurons for in vitro experiments. Cultures should be prepared from cells …

The purpose of this study is to investigate whether calpastatin (CAST) plays an important
role in the regulated necrosis (RN) in rat retinal neurons under an excessive glutamate …

Background Major depressive disorder (MDD) is a severe mental disorder characterized by
reduced gray matter volume (GMV). To date, the pathogenesis of MDD remains unclear, but …

Intestinal inflammation challenges both function and structure of the enteric nervous system
(ENS). In the animal model of TNBS-induced colitis, an influx of immune cells causes early …