Modular peptide synthetases involved in nonribosomal peptide synthesis
MA Marahiel, T Stachelhaus, HD Mootz - Chemical reviews, 1997 - ACS Publications
Significant progress has been made in the past four decades toward understanding the
structures and synthesis of bioactive peptides produced by microorganisms through the …
structures and synthesis of bioactive peptides produced by microorganisms through the …
Genetic contributions to understanding polyketide synthases
DA Hopwood - Chemical reviews, 1997 - ACS Publications
Over the last eight years or so, genetic techniques have spearheaded significant advances
in our understanding of the structure and mechanisms of polyketide synthases (PKSs). Much …
in our understanding of the structure and mechanisms of polyketide synthases (PKSs). Much …
Structural organization of microcystin biosynthesis in Microcystis aeruginosa PCC7806: an integrated peptide–polyketide synthetase system
D Tillett, E Dittmann, M Erhard, H Von Döhren… - Chemistry & biology, 2000 - cell.com
Background: Blooms of toxic cyanobacteria (blue-green algae) have become increasingly
common in the surface waters of the world. Of the known toxins produced by cyanobacteria …
common in the surface waters of the world. Of the known toxins produced by cyanobacteria …
The biosynthetic gene cluster for the polyketide immunosuppressant rapamycin.
T Schwecke, JF Aparicio, I Molnar… - Proceedings of the …, 1995 - National Acad Sciences
The macrocyclic polyketides rapamycin and FK506 are potent immunosuppressants that
prevent T-cell proliferation through specific binding to intracellular protein receptors …
prevent T-cell proliferation through specific binding to intracellular protein receptors …
Widespread occurrence of three sequence motifs in diverse S-adenosylmethionine-dependent methyltransferases suggests a common structure for these enzymes
RM Kagan, S Clarke - Archives of biochemistry and biophysics, 1994 - Elsevier
Three regions of sequence similarity have been reported in several protein and small-
molecule S-adenosylmethionine-dependent methyltransferases. Using multiple alignments …
molecule S-adenosylmethionine-dependent methyltransferases. Using multiple alignments …
A hidden Markov model that finds genes in E.coli DNA
A Krogh, IS Mian, D Haussler - Nucleic acids research, 1994 - academic.oup.com
A hidden Markov model (HMM) has been developed to find protein coding genes in E. coli
DNA using E. coli genome DNA sequence from the EcoSeq6 database maintained by Kenn …
DNA using E. coli genome DNA sequence from the EcoSeq6 database maintained by Kenn …
Biosynthesis of the ansamycin antibiotic rifamycin: deductions from the molecular analysis of the rif biosynthetic gene cluster of Amycolatopsis mediterranei S699
Background: The ansamycin class of antibiotics are produced by various Actinomycetes.
Their carbon framework arises from the polyketide pathway via a polyketide synthase (PKS) …
Their carbon framework arises from the polyketide pathway via a polyketide synthase (PKS) …
Genetic engineering of modular PKSs: from combinatorial biosynthesis to synthetic biology
KJ Weissman - Natural product reports, 2016 - pubs.rsc.org
Covering: up to 2015 Multienzyme polyketide synthases (PKSs) are molecular-scale
assembly lines which construct complex natural products in bacteria. The underlying …
assembly lines which construct complex natural products in bacteria. The underlying …
Biosynthesis of phosphatidylcholine in bacteria
Phosphatidylcholine (PC) is the major membrane-forming phospholipid in eukaryotes and
can be synthesized by either of two pathways, the methylation pathway or the CDP-choline …
can be synthesized by either of two pathways, the methylation pathway or the CDP-choline …
Polyketide synthesis: prospects for hybrid antibiotics
L Katz, S Donadio - Annual review of microbiology, 1993 - go.gale.com
Aromatic and complex polyketides are produced by the condensation of carboxylic acids.
They exhibit antibacterial, antifungal and anthelmintic properties and are produced by fungi …
They exhibit antibacterial, antifungal and anthelmintic properties and are produced by fungi …