[HTML][HTML] Inflammation, not cholesterol, is a cause of chronic disease

A Tsoupras, R Lordan, I Zabetakis - Nutrients, 2018 - mdpi.com
Since the Seven Countries Study, dietary cholesterol and the levels of serum cholesterol in
relation to the development of chronic diseases have been somewhat demonised. However …

Platelet activation and prothrombotic mediators at the nexus of inflammation and atherosclerosis: Potential role of antiplatelet agents

R Lordan, A Tsoupras, I Zabetakis - Blood reviews, 2021 - Elsevier
Platelets are central to inflammation-related manifestations of cardiovascular diseases
(CVD) such as atherosclerosis. Platelet-activating factor (PAF), thrombin, thromboxane A 2 …

Phospholipids of animal and marine origin: Structure, function, and anti-inflammatory properties

R Lordan, A Tsoupras, I Zabetakis - Molecules, 2017 - mdpi.com
In this review paper, the latest literature on the functional properties of phospholipids in
relation to inflammation and inflammation-related disorders has been critically appraised …

Forty years since the structural elucidation of platelet-activating factor (PAF): historical, current, and future research perspectives

R Lordan, A Tsoupras, I Zabetakis, CA Demopoulos - Molecules, 2019 - mdpi.com
In the late 1960s, Barbaro and Zvaifler described a substance that caused antigen induced
histamine release from rabbit platelets producing antibodies in passive cutaneous …

Protective effect of olive oil microconstituents in atherosclerosis: emphasis on PAF implicated atherosclerosis theory

S Antonopoulou, CA Demopoulos - Biomolecules, 2023 - mdpi.com
Atherosclerosis is a progressive vascular multifactorial process. The mechanisms
underlining the initiating event of atheromatous plaque formation are inflammation and …

Micronutrients, phytochemicals and mediterranean diet: A potential protective role against COVID-19 through modulation of PAF actions and metabolism

P Detopoulou, CA Demopoulos, S Antonopoulou - Nutrients, 2021 - mdpi.com
The new coronavirus disease 2019 (COVID-19) pandemic is an emerging situation with high
rates of morbidity and mortality, in the pathophysiology of which inflammation and …

Inflammation and cardiovascular disease: are marine phospholipids the answer?

R Lordan, S Redfern, A Tsoupras, I Zabetakis - Food & Function, 2020 - pubs.rsc.org
Since the discovery that Greenlandic Innuits had a lower risk of develo** cardiovascular
diseases (CVD) due to their diet of fish and as a consequence high polyunsaturated fatty …

[HTML][HTML] Cardiovascular diseases and marine oils: a focus on omega-3 polyunsaturated fatty acids and polar lipids

C Caffrey, A Leamy, E O'Sullivan, I Zabetakis, R Lordan… - Marine Drugs, 2023 - mdpi.com
Cardiovascular diseases (CVD) remain the leading cause of death across the globe, hence,
establishing strategies to counteract CVD are imperative to reduce mortality and the burden …

Mediterranean diet and platelet-activating factor; a systematic review

T Nomikos, E Fragopoulou, S Antonopoulou… - Clinical …, 2018 - Elsevier
Platelet-activating factor (PAF) is a glycerylether lipid and one of the most potent
endogenous mediators of inflammation. Through its binding to a well-characterized receptor …

Cardio-protective properties and health benefits of fish lipid bioactives; the effects of thermal processing

A Tsoupras, C Brummell, C Kealy, K Vitkaitis… - Marine Drugs, 2022 - mdpi.com
The beneficial effects of fish-derived lipid bioactives have come to prominence over the last
few decades, especially for their utilization in fish oils, supplements, and nutraceuticals …