State-of-the-art review of lung imaging in cystic fibrosis with recommendations for pulmonologists and radiologists from the “iMAging managEment of cySTic fibROsis” …

P Ciet, S Bertolo, M Ros, R Casciaro… - European …, 2022 - Eur Respiratory Soc
Objective Imaging represents an important noninvasive means to assess cystic fibrosis (CF)
lung disease, which remains the main cause of morbidity and mortality in CF patients. While …

The radiological diagnosis of bronchiectasis: what's in a name?

HAWM Tiddens, JJ Meerburg… - European …, 2020 - Eur Respiratory Soc
Diagnosis of bronchiectasis is usually made using chest computed tomography (CT) scan,
the current gold standard method. A bronchiectatic airway can show abnormal widening and …

Diagnosis of bronchiectasis and airway wall thickening in children with cystic fibrosis: objective airway-artery quantification

W Kuo, M de Bruijne, J Petersen, K Nasserinejad… - European …, 2017 - Springer
Objectives To quantify airway and artery (AA)-dimensions in cystic fibrosis (CF) and control
patients for objective CT diagnosis of bronchiectasis and airway wall thickness (AWT) …

Structural lung disease and clinical phenotype in bronchiectasis patients: the EMBARC CT study

ALP Pieters, T van der Veer, JJ Meerburg… - American Journal of …, 2024 - atsjournals.org
Rationale: Chest computed tomography (CT) scans are essential to diagnose and monitor
bronchiectasis (BE). To date, few quantitative data are available about the nature and extent …

The effect of CFTR modulators on structural lung disease in cystic fibrosis

LC Mok, A Garcia-Uceda, MN Cooper… - Frontiers in …, 2023 - frontiersin.org
Background: Newly developed quantitative chest computed tomography (CT) outcomes
designed specifically to assess structural abnormalities related to cystic fibrosis (CF) lung …

Automatic analysis of bronchus-artery dimensions to diagnose and monitor airways disease in cystic fibrosis

Q Lv, L Gallardo-Estrella, ER Andrinopoulou, Y Chen… - thorax, 2024 - thorax.bmj.com
Background Cystic fibrosis (CF) lung disease is characterised by progressive airway wall
thickening and widening. We aimed to validate an artificial intelligence-based algorithm to …

[HTML][HTML] Chest imaging in cystic fibrosis studies: what counts, and can be counted?

R Szczesniak, L Turkovic, ER Andrinopoulou… - Journal of Cystic …, 2017 - Elsevier
Background The dawn of precision medicine and CFTR modulators require more detailed
assessment of lung structure in cystic fibrosis (CF) clinical studies. Various imaging markers …

Airway tapering: an objective image biomarker for bronchiectasis

W Kuo, A Perez-Rovira, H Tiddens, M de Bruijne - European radiology, 2020 - Springer
Purpose To estimate airway tapering in control subjects and to assess the usability of
tapering as a bronchiectasis biomarker in paediatric populations. Methods Airway tapering …

The clinical impact of Lumacaftor-Ivacaftor on structural lung disease and lung function in children aged 6–11 with cystic fibrosis in a real-world setting

P McNally, B Linnane, M Williamson, B Elnazir… - Respiratory …, 2023 - Springer
Background Data from clinical trials of lumacaftor-ivacaftor (LUM-IVA) demonstrate
improvements in lung clearance index (LCI) but not in FEV1 in children with Cystic Fibrosis …

Automated method of bronchus and artery dimension measurement in an adult bronchiectasis population

ALP Pieters, Q Lv, JJ Meerburg… - ERJ Open …, 2024 - publications.ersnet.org
Aim Bronchiectasis (BE) is a disease defined by irreversible dilatation of the airway.
Computed tomography (CT) plays an important role in the detection and quantification of BE …