Role of animal models in biomedical research: a review

P Mukherjee, S Roy, D Ghosh, SK Nandi - Laboratory Animal Research, 2022 - Springer
The animal model deals with the species other than the human, as it can imitate the disease
progression, its' diagnosis as well as a treatment similar to human. Discovery of a drug …

Streptozotocin as a tool for induction of rat models of diabetes: A practical guide

A Ghasemi, S Jeddi - EXCLI journal, 2023 - pmc.ncbi.nlm.nih.gov
Streptozotocin (STZ) is the most used diabetogenic chemical for creating rat models of type
1 and type 2 diabetes. Despite~ 60 years of using STZ in animal diabetes research, some …

A novel “hot spring”-mimetic hydrogel with excellent angiogenic properties for chronic wound healing

L Sheng, Z Zhang, Y Zhang, E Wang, B Ma, Q Xu, L Ma… - Biomaterials, 2021 - Elsevier
The treatment of chronic wounds is a major challenge in regenerative medicine, and
angiogenesis is known to be critical for chronic wound healing. Hot springs with temperature …

[BOEK][B] Nutraceuticals and dietary supplements: Applications in health improvement and disease management

RK Keservani, AK Sharma, RK Kesharwani - 2020 - books.google.com
Addressing the increasing popularity of nutraceuticals, dietary supplements, and functional
foods, this comprehensive and timely book presents an abundance of information on herbal …

The impact of maternal diabetes on the future health and neurodevelopment of the offspring: a review of the evidence

K Rodolaki, V Pergialiotis, N Iakovidou… - Frontiers in …, 2023 - frontiersin.org
Maternal health during gestational period is undoubtedly critical in sha** optimal fetal
development and future health of the offspring. Gestational diabetes mellitus is a metabolic …

Acetate and butyrate improve β-cell metabolism and mitochondrial respiration under oxidative stress

S Hu, R Kuwabara, BJ de Haan, AM Smink… - International journal of …, 2020 - mdpi.com
Islet dysfunction mediated by oxidative and mitochondrial stress contributes to the
development of type 1 and 2 diabetes. Acetate and butyrate, produced by gut microbiota via …

Analytical and biochemical perspectives of protein O-GlcNAcylation

J Ma, C Wu, GW Hart - Chemical Reviews, 2021 - ACS Publications
Protein O-linked β-N-acetylglucosamine (O-GlcNAc) modification (O-GlcNAcylation) is a
unique monosaccharide modification discovered in the early 1980s. With the technological …

Understanding glycaemic control and current approaches for screening antidiabetic natural products from evidence-based medicinal plants

C Lankatillake, T Huynh, DA Dias - Plant Methods, 2019 - Springer
Abstract Type 2 Diabetes Mellitus has reached epidemic proportions as a result of over-
nutrition and increasingly sedentary lifestyles. Current therapies, although effective, are not …

Aloe vera and Streptozotocin-Induced Diabetes Mellitus

F Haghani, MR Arabnezhad, S Mohammadi… - Revista Brasileira de …, 2022 - Springer
Diabetes mellitus is defined as prolonged hyperglycemia, which can harm the eyes, kidneys,
and cardiovascular and neurological systems. Herbal agents and their derived supplements …

An integrated iterative annotation technique for easing neural network training in medical image analysis

B Lutnick, B Ginley, D Govind, SD McGarry… - Nature machine …, 2019 - nature.com
Neural networks promise to bring robust, quantitative analysis to medical fields. However,
their adoption is limited by the technicalities of training these networks and the required …