ApoE is the major lipid and cholesterol carrier in the CNS. There are three major human
polymorphisms, apoE2, apoE3, and apoE4, and the genetic expression of APOE4 is one of …

Objective Physical activity (PA) is associated with a decreased incidence of dementia, but
much of the evidence comes from short follow-ups prone to reverse causation. This meta …

Is the field of cognitive aging irretrievably concerned with decline and deficits, or is it shifting
to emphasize the hope of preservation and enhancement of cognitive function in late life? A …

This review proposes that physical inactivity could be considered a behavior selected by
evolution for resting, and also selected to be reinforcing in life-threatening situations in …

This review provides the reader with the up‐to‐date evidence‐based basis for prescribing
exercise as medicine in the treatment of 26 different diseases: psychiatric diseases …

Non-pharmacological therapies, such as physical activity interventions, are an appealing
alternative or add-on to current pharmacological treatment of cognitive symptoms in patients …

Background: Alzheimer's disease (AD) and dementia are chronic diseases with progressive
deterioration of cognition, function, and behavior leading to severe disability and death. The …

As the population ages due to demographic trends and gains in life expectancy, the
incidence and prevalence of dementia increases, and the need to understand the etiology …

Stress is viewed as a state of real or perceived threat to homeostasis, the management of
which involves the endocrine, nervous, and immune systems. These systems work …

Background The treatment of noncommunicable diseases (NCD), like coronary heart
disease or type 2 diabetes mellitus, causes rising costs for the health system. Physical …