Surface modifications for implants lifetime extension: an overview of sol-gel coatings

E Tranquillo, F Bollino - Coatings, 2020 - mdpi.com
The limited lifetime of implants entails having patients undergo replacement surgeries,
several times throughout life in young patients, with significant risks for them and extensive …

Tissue‐engineered peripheral nerve interfaces

BS Spearman, VH Desai, S Mobini… - Advanced Functional …, 2018 - Wiley Online Library
Research on neural interfaces has historically concentrated on development of systems for
the brain; however, there is increasing interest in peripheral nerve interfaces (PNIs) that …

Amperometric detection of dopamine in vivo with an enzyme based carbon fiber microbiosensor

J Njagi, MM Chernov, JC Leiter… - Analytical chemistry, 2010 - ACS Publications
We developed a novel implantable enzyme-based carbon fiber biosensor for in vivo
monitoring of dopamine. The biosensor is fabricated using tyrosinase immobilized in a …

In Vivo Electrochemical Analysis of a PEDOT/MWCNT Neural Electrode Coating

NA Alba, ZJ Du, KA Catt, TDY Kozai, XT Cui - Biosensors, 2015 - mdpi.com
Neural electrodes hold tremendous potential for improving understanding of brain function
and restoring lost neurological functions. Multi-walled carbon nanotube (MWCNT) and …

Polymer composite with carbon nanofibers aligned during thermal drawing as a microelectrode for chronic neural interfaces

Y Guo, S Jiang, BJB Grena, IF Kimbrough… - Acs Nano, 2017 - ACS Publications
Microelectrodes provide a direct pathway to investigate brain activities electrically from the
external world, which has advanced our fundamental understanding of brain functions and …

Protease-degradable PEG-maleimide coating with on-demand release of IL-1Ra to improve tissue response to neural electrodes

SM Gutowski, JT Shoemaker, KL Templeman, Y Wei… - Biomaterials, 2015 - Elsevier
Neural electrodes are an important part of brain-machine interface devices that can restore
functionality to patients with sensory and movement disorders. Chronically implanted neural …

Foreign body response to intracortical microelectrodes is not altered with dip-coating of polyethylene glycol (PEG)

HC Lee, J Gaire, SW Currlin, MD McDermott… - Frontiers in …, 2017 - frontiersin.org
Poly (ethylene glycol)(PEG) is a frequently used polymer for neural implants due to its
biocompatible property. As a follow-up to our recent study that used PEG for stiffening …

Materials approaches for modulating neural tissue responses to implanted microelectrodes through mechanical and biochemical means

S Sommakia, HC Lee, J Gaire, KJ Otto - Current Opinion in Solid State and …, 2014 - Elsevier
Implantable intracortical microelectrodes face an uphill struggle for widespread clinical use.
Their potential for treating a wide range of traumatic and degenerative neural disease is …

Sol-gel coatings doped with graphene nanoplatelets for improving the degradation rate and the cytocompatibility of AZ31 alloy for biomedical applications

JP Fernández-Hernán, B Torres, AJ López… - Surface and Coatings …, 2021 - Elsevier
SiO 2 coatings doped with four different functionalized graphene nanoplatelets (COOH-
GNPs) concentrations (from 0.005 to 1 wt%) were deposited on AZ31 magnesium substrates …

Resistive and reactive changes to the impedance of intracortical microelectrodes can be mitigated with polyethylene glycol under acute in vitro and in vivo settings

S Sommakia, J Gaire, JL Rickus… - Frontiers in …, 2014 - frontiersin.org
The reactive response of brain tissue to implantable intracortical microelectrodes is thought
to negatively affect their recordable signal quality and impedance, resulting in unreliable …