Overview of the most promising radionuclides for targeted alpha therapy: The “hopeful eight”
Among all existing radionuclides, only a few are of interest for therapeutic applications and
more specifically for targeted alpha therapy (TAT). From this selection, actinium-225 …
more specifically for targeted alpha therapy (TAT). From this selection, actinium-225 …
Advances in the Chemistry of Astatine and Implications for the Development of Radiopharmaceuticals
Conspectus Astatine (At) is the rarest on Earth of all naturally occurring elements, situated
below iodine in the periodic table. While only short-lived isotopes (t 1/2≤ 8.1 h) are known …
below iodine in the periodic table. While only short-lived isotopes (t 1/2≤ 8.1 h) are known …
Recent progress of astatine-211 in endoradiotherapy: Great advances from fundamental properties to targeted radiopharmaceuticals
F Li, Y Yang, J Liao, N Liu - Chinese Chemical Letters, 2022 - Elsevier
Abstract Astatine-211 (211 At, t 1/2= 7.21 h) emitting two α particles with energies of 5.87
and 7.45 MeV, can lead to a high linear energy transfer (LET= 98.84 keV/µm) and short …
and 7.45 MeV, can lead to a high linear energy transfer (LET= 98.84 keV/µm) and short …
Experimental and computational evidence of halogen bonds involving astatine
The importance of halogen bonds—highly directional interactions between an electron-
deficient σ-hole moiety in a halogenated compound and an acceptor such as a Lewis base …
deficient σ-hole moiety in a halogenated compound and an acceptor such as a Lewis base …
Investigation on the reactivity of nucleophilic radiohalogens with arylboronic acids in water: access to an efficient single-step method for the radioiodination and …
M Berdal, S Gouard, R Eychenne… - Chemical …, 2021 - pubs.rsc.org
Easy access to radioiodinated and 211At-labelled bio (macro) molecules is essential to
develop new strategies in nuclear imaging and targeted radionuclide therapy of cancers …
develop new strategies in nuclear imaging and targeted radionuclide therapy of cancers …
Synthesis of [211At]4-astato-L-phenylalanine by dihydroxyboryl-astatine substitution reaction in aqueous solution
Abstract Astatine-211 (211At)-labeled phenylalanine is expected to be a promising agent for
targeted alpha-particle therapy for the treatment of patients with glioma. The existing …
targeted alpha-particle therapy for the treatment of patients with glioma. The existing …
Targeted radionuclide therapy with astatine-211: Oxidative dehalogenation of astatobenzoate conjugates
Abstract 211At is a most promising radionuclide for targeted alpha therapy. However, its
limited availability and poorly known basic chemistry hamper its use. Based on the analogy …
limited availability and poorly known basic chemistry hamper its use. Based on the analogy …
Complexation of Astatine(III) with Ketones: Roles of NO3– Counterion and Exploration of Possible Binding Modes
Ketones have been proven effective in extracting astatine (III) from aqueous solvents.
Previous theoretical studies suggested a mechanism where the “sp2” lone pair on the …
Previous theoretical studies suggested a mechanism where the “sp2” lone pair on the …
Pourbaix diagram of astatine revisited: experimental investigations
The Pourbaix diagram of an element displays its stable chemical forms with respect to the
redox potential and pH of the solution, whose knowledge is fundamental for understanding …
redox potential and pH of the solution, whose knowledge is fundamental for understanding …
Mechanism of astatine and bismuth sorption on extraction chromatography resins from nitric acid media
Systematic study of astatine (At) sorption on extraction chromatography resins from nitric
acid media has been performed at Texas A&M University. This work covers commercially …
acid media has been performed at Texas A&M University. This work covers commercially …