Abstract The coronavirus disease 2019 (COVID-19) pandemic has stimulated tremendous
efforts to develop therapeutic strategies that target severe acute respiratory syndrome …

Continually repeating outbreaks of pathogenic viruses necessitate the construction of
effective antiviral strategies. Therefore, the development of new specific antiviral drugs in a …

The world was unprepared for coronavirus disease 2019 (COVID-19) and remains ill-
equipped for future pandemics. While unprecedented strides have been made develo** …

The COVID-19 pandemic has spurred intense research efforts to identify effective treatments
for SARS-CoV-2. In silico studies have emerged as a powerful tool in the drug discovery …

Emerging new variants of SARS-CoV-2 and inevitable acquired drug resistance call for the
continued search of new pharmacological targets to fight the potentially fatal infection. Here …

Highlights•Mutation informatics study on RBD of SARS-CoV-2 variants.•Discussion of small
molecules targeting the RBD/ACE2 interface.•Ideation to design novel inhibitors against wild …

Despite considerable progress in develo** vaccines and antivirals to combat COVID-19,
the rapid mutations of the SARS-CoV-2 genome have limited the durability and efficacy of …

The emergence of fast-spreading SARS-CoV-2 mutants has sparked a new phase of COVID-
19 pandemic. There is a dire necessity for antivirals targeting highly conserved genomic …

COVID-19 caused by SARS-CoV-2 has raised a health crisis worldwide. The high morbidity
and mortality associated with COVID-19 and the lack of effective drugs or vaccines for SARS …

This article evaluated the in vitro antiviral effect of atorvastatin (ATV) against SARS-CoV-2
and identified the interaction affinity between this compound and two SARS-CoV-2 proteins …