Metastatic biopsy programmes combined with advances in genomic sequencing have
provided new insights into the molecular landscape of castration-resistant prostate cancer …

The molecular chaperone heat shock protein 90 (HSP90) has been used by cancer cells to
facilitate the function of numerous oncoproteins, and it can be argued that cancer cells …

Purpose: Prostate cancer translational research has been hampered by the lack of
comprehensive and tractable models that represent the genomic landscape of clinical …

The androgen receptor (AR), ligand-induced transcription factor, is expressed in primary
prostate cancer and in metastases. AR regulates multiple cellular events, proliferation …

Despite new treatments for castrate-resistant prostate cancer (CRPC), the prognosis of
patients with CRPC remains bleak due to acquired resistance to androgen receptor (AR) …

Benign prostatic hyperplasia (BPH) is a benign enlargement of the prostate in which
incidence increases linearly with age, beginning at about 50 years old. BPH is a significant …

Modern classification of the family of human small heat shock proteins (the so-called HSPB)
is presented, and the structure and properties of three members of this family are analyzed …

As prostate cancer and aberrant changes in reactive oxygen species (ROS) become more
common with aging, ROS signaling may play an important role in the development and …

Hsp27, αB-crystallin and HSP22 are ubiquitous small heat shock proteins (sHsp) whose
expression is induced in response to a wide variety of unfavorable physiological and …

Heat shock proteins (HSP) are a subset of the molecular chaperones, best known for their
rapid and abundant induction by stress. HSP genes are activated at the transcriptional level …