Zinc metabolism at the cellular level is critical for many biological processes in the body. A
key observation is the disruption of cellular homeostasis, often coinciding with disease …

Cancers undergo sequential changes to proton (H+) concentration and sensing that are
consequences of the disease and facilitate its further progression. The impact of protonation …

Lactate has long been considered a cellular waste product. However, we found that as
extracellular lactate accumulates, it also enters the mitochondrial matrix and stimulates …

Aberrant lysine lactylation (Kla) is associated with various diseases which are caused by
excessive glycolysis metabolism. However, the regulatory molecules and downstream …

Cardiovascular diseases pose a major threat worldwide. Common cardiovascular diseases
include acute myocardial infarction (AMI), heart failure, atrial fibrillation (AF) and …

The relationship between metabolism and cell cycle progression is complex and
bidirectional. Cells must rewire metabolism to meet changing biosynthetic demands across …

Posttranslational modification by small ubiquitin-like modifiers (SUMOs) is critical in
regulating diverse cellular processes including gene expression, cell cycle progression …

There is growing evidence that lactate can have a wide range of biological impacts in
addition to being a waste product of metabolism. Because of the Warburg effect, tumors …

Although nontumor components play an essential role in colon cancer (CC) progression, the
intercellular communication between CC cells and adjacent colonic epithelial cells (CECs) …

It remains a tremendous challenge to explore effective therapeutic modalities against
neuroblastoma, a lethal cancer of the sympathetic nervous system with poor prognosis and …