Cancers undergo sequential changes to proton (H+) concentration and sensing that are
consequences of the disease and facilitate its further progression. The impact of protonation …

Zinc metabolism at the cellular level is critical for many biological processes in the body. A
key observation is the disruption of cellular homeostasis, often coinciding with disease …

Lactate has long been considered a cellular waste product. However, we found that as
extracellular lactate accumulates, it also enters the mitochondrial matrix and stimulates …

The relationship between metabolism and cell cycle progression is complex and
bidirectional. Cells must rewire metabolism to meet changing biosynthetic demands across …

Overproduction of lactate (LA) can occur during exercise and in many diseases such as
cancers. Individuals with hyperlactatemia often display anemia, decreased serum iron, and …

Posttranslational modification by small ubiquitin-like modifiers (SUMOs) is critical in
regulating diverse cellular processes including gene expression, cell cycle progression …

The ability of vertebrates to 'remember'previous infections had once been attributed
exclusively to adaptive immunity. We now appreciate that innate lymphocytes also possess …

Histone lysine lactylation is a physiologically and pathologically relevant epigenetic pathway
that can be stimulated by the Warburg effect-associated L-lactate. Nevertheless, the …

Living probiotics secrete bioactive substances to accelerate wound healing, but the clinical
application of antibiotics inhibits the survival of probiotics. Inspired by the chelation of tannic …

By the time a tumor reaches clinical detectability, it contains around 108–109 cells.
However, during tumor formation, significant cell loss occurs due to cell death. In some …