Colorectal cancer (CRC), a multifactorial disease, is usually induced and developed through
complex mechanisms, including impact of diet and lifestyle, genomic abnormalities, change …

The tumor microenvironment (TME) is characterized by an acidic pH and low oxygen
concentrations. Hypoxia induces neoplastic cell evasion of the immune surveillance, rapid …

Background: Matrix metalloproteinases (MMPs) are capable of degrading and modifying
most components of the extracellular matrix (ECM) and the basal membrane (BM), and play …

Introduction ARHGAP10 belongs to the ARHGAP family, which is downregulated in certain
human tumors. However, the detailed function of ARHGAP10 remains unclear in human …

CRC is the second leading cause of cancer-related death. The complex mechanisms of
metastatic CRC limit available therapeutic choice. Thus, identifying new CRC therapeutic …

Sinomenine (SIN) has been reported its antitumor effects on various types of human
cancers, but there is no available information regarding the antitumor effects of SIN and …

Matrix metalloproteinase (MMP)-2 and-9, which degrade type IV collagen, are linked to
cancer invasion and metastasis. Gene polymorphisms in MMP-2 and MMP-9 can influence …

Abstract Background/Aim: Matrix metalloproteinase-2 (MMP2) has been reported to plays a
critical role in the metastatic behaviors of cancer via regulation of the extracellular matrix …

KLF2, a member of the Kruppel-like factor (KLF) family, is thought to be a tumor suppressor
in many kinds of malignant tumors. Its functions in prostate cancer (PCa) are unknown. This …

Herein, we found ARHGAP25 was down-regulated in colon biopsies of patients with
colorectal cancer (CRC). Gene set enrichment analysis (GSEA) also showed that …