PIWI-interacting RNAs (piRNAs) are a class of small non-coding RNAs that associate with
proteins of the PIWI clade of the Argonaute family. First identified in animal germ line cells …

RNA molecules start assembling into ribonucleoprotein (RNP) complexes during
transcription. Dynamic RNP assembly, largely directed by cis-acting elements on the RNA …

In animals, PIWI-interacting RNAs (piRNAs) of 21–35 nucleotides in length silence
transposable elements, regulate gene expression and fight viral infection. piRNAs guide …

The PIWI-interacting RNA (piRNA) pathway is a conserved defense mechanism that protects
the genetic information of animal germ cells from the deleterious effects of molecular …

Two decades after the discovery of the first animal microRNA (miRNA), the number of
miRNAs in animal genomes remains a vexing question. Here, we report findings from …

Spermiogenesis is a highly orchestrated developmental process during which chromatin
condensation decouples transcription from translation. Spermiogenic mRNAs are …

In animal gonads, PIWI-clade Argonaute proteins repress transposons sequence-
specifically via bound Piwi-interacting RNAs (piRNAs). These are processed from single …

Distinguishing self from non-self plays a crucial role in safeguarding the germlines of
metazoa from mobile DNA elements. Since their discovery less than a decade ago, Piwi …

Piwi-interacting RNAs (piRNAs) silence transposons to safeguard genome integrity in
animals. However, the functions of the many piRNAs that do not map to transposons remain …

Spermatogenesis in mammals is characterized by two waves of piRNA expression: one
corresponds to classic piRNAs responsible for silencing retrotransponsons and the second …