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A quantitative approach to predicting lung deposition profiles of pharmaceutical powder aerosols
Dry powder inhalers (DPI) are widely used systems for pulmonary delivery of therapeutics.
The inhalation performance of DPIs is influenced by formulation features, inhaler device and …
The inhalation performance of DPIs is influenced by formulation features, inhaler device and …
Flow structure and particle deposition analyses for optimization of a pressurized metered dose inhaler (pMDI) in a model of tracheobronchial airway
Inhalation therapy plays an important role in management or treatment of respiratory
diseases such asthma and chronic obstructive pulmonary diseases (COPDs). For decades …
diseases such asthma and chronic obstructive pulmonary diseases (COPDs). For decades …
[HTML][HTML] Nanoparticle transport and deposition in a heterogeneous human lung airway tree: An efficient one path model for CFD simulations
Understanding nano-particle inhalation in human lung airways helps targeted drug delivery
for treating lung diseases. A wide range of numerical models have been developed to …
for treating lung diseases. A wide range of numerical models have been developed to …
In silico evaluation of particle transport and deposition in the airways of individual patients with chronic obstructive pulmonary disease
K Kadota, K Matsumoto, H Uchiyama, S Tobita… - European Journal of …, 2022 - Elsevier
Inhalation therapy can effectively treat chronic obstructive pulmonary disease (COPD), but
the physical factors determining the appropriate aerosol delivery into the targeted airways …
the physical factors determining the appropriate aerosol delivery into the targeted airways …
Non-spherical drug particle deposition in human airway using computational fluid dynamics and discrete element method
S Tanprasert, C Kampeewichean, S Shiratori… - International Journal of …, 2023 - Elsevier
Currently, the air pollution and the respiratory disease problems that affect human health are
increasing rapidly. Hence, there is attention for trend prediction of the located deposition of …
increasing rapidly. Hence, there is attention for trend prediction of the located deposition of …
[HTML][HTML] Effects of the deformation and size of the upper airway on the deposition of aerosols
Aerosol drug delivery in the human airway is significantly affected by the morphology and
size of the airway. This work developed a CFD-DEM model to simulate and analyze air flow …
size of the airway. This work developed a CFD-DEM model to simulate and analyze air flow …
Emerging Process Modeling Capabilities for Dry Powder Operations for Inhaled Formulations
Dry powder inhaler (DPI) products are commonly formulated as a mixture of micronized drug
particles and large carrier particles, with or without additional fine particle excipients …
particles and large carrier particles, with or without additional fine particle excipients …
[HTML][HTML] Sources and health effects of fine and ultrafine aerosol particles in an urban environment
V Groma, B Alföldy, E Börcsök, O Czömpöly… - Atmospheric Pollution …, 2022 - Elsevier
The implementation of a liveable urban environment is a challenge for decision makers
since cities are typically more and more heavily congested with traffic. The aims of the …
since cities are typically more and more heavily congested with traffic. The aims of the …
Analysis of microparticle deposition in the human lung by taguchi method and response surface methodology
The deposition phenomenon of microparticle and SAR-CoV-2 laced bioaerosol in human
airways is studied by Taguchi methods and response surface methodology (RSM). The data …
airways is studied by Taguchi methods and response surface methodology (RSM). The data …
Numerical study on the effect of the realistic mouth-inhaler positions on orally inhaled drug delivery in pediatric intersubject upper airways
The relative position between the pediatric upper airway and the inhalation device during
real inhalation administration has significant effects on the delivery efficiency of orally …
real inhalation administration has significant effects on the delivery efficiency of orally …