A quantitative approach to predicting lung deposition profiles of pharmaceutical powder aerosols

S Yaqoubi, HK Chan, A Nokhodchi… - International Journal of …, 2021 - Elsevier
Dry powder inhalers (DPI) are widely used systems for pulmonary delivery of therapeutics.
The inhalation performance of DPIs is influenced by formulation features, inhaler device and …

Flow structure and particle deposition analyses for optimization of a pressurized metered dose inhaler (pMDI) in a model of tracheobronchial airway

K Ahookhosh, M Saidi, M Mohammadpourfard… - European Journal of …, 2021 - Elsevier
Inhalation therapy plays an important role in management or treatment of respiratory
diseases such asthma and chronic obstructive pulmonary diseases (COPDs). For decades …

[HTML][HTML] Nanoparticle transport and deposition in a heterogeneous human lung airway tree: An efficient one path model for CFD simulations

MM Rahman, M Zhao, MS Islam, K Dong… - European Journal of …, 2022 - Elsevier
Understanding nano-particle inhalation in human lung airways helps targeted drug delivery
for treating lung diseases. A wide range of numerical models have been developed to …

In silico evaluation of particle transport and deposition in the airways of individual patients with chronic obstructive pulmonary disease

K Kadota, K Matsumoto, H Uchiyama, S Tobita… - European Journal of …, 2022 - Elsevier
Inhalation therapy can effectively treat chronic obstructive pulmonary disease (COPD), but
the physical factors determining the appropriate aerosol delivery into the targeted airways …

Non-spherical drug particle deposition in human airway using computational fluid dynamics and discrete element method

S Tanprasert, C Kampeewichean, S Shiratori… - International Journal of …, 2023 - Elsevier
Currently, the air pollution and the respiratory disease problems that affect human health are
increasing rapidly. Hence, there is attention for trend prediction of the located deposition of …

[HTML][HTML] Effects of the deformation and size of the upper airway on the deposition of aerosols

D Gou, Q Zhu, HK Chan, A Kourmatzis, S Cheng… - International Journal of …, 2024 - Elsevier
Aerosol drug delivery in the human airway is significantly affected by the morphology and
size of the airway. This work developed a CFD-DEM model to simulate and analyze air flow …

Emerging Process Modeling Capabilities for Dry Powder Operations for Inhaled Formulations

H Lou, L Ding, T Wu, W Li, R Khalaf… - Molecular …, 2023 - ACS Publications
Dry powder inhaler (DPI) products are commonly formulated as a mixture of micronized drug
particles and large carrier particles, with or without additional fine particle excipients …

[HTML][HTML] Sources and health effects of fine and ultrafine aerosol particles in an urban environment

V Groma, B Alföldy, E Börcsök, O Czömpöly… - Atmospheric Pollution …, 2022 - Elsevier
The implementation of a liveable urban environment is a challenge for decision makers
since cities are typically more and more heavily congested with traffic. The aims of the …

Analysis of microparticle deposition in the human lung by taguchi method and response surface methodology

WH Chen, CM Chang, JK Mutuku, SS Lam… - Environmental Research, 2021 - Elsevier
The deposition phenomenon of microparticle and SAR-CoV-2 laced bioaerosol in human
airways is studied by Taguchi methods and response surface methodology (RSM). The data …

Numerical study on the effect of the realistic mouth-inhaler positions on orally inhaled drug delivery in pediatric intersubject upper airways

X Zhou, Y Li, H Miao, Y Zhang, A Yu, F Huang, R Li… - Powder technology, 2024 - Elsevier
The relative position between the pediatric upper airway and the inhalation device during
real inhalation administration has significant effects on the delivery efficiency of orally …