Genomic DNA is folded into loops and topologically associating domains (TADs), which
serve important structural and regulatory roles. It has been proposed that these genomic …

ATP-binding cassette (ABC) transporters constitute one of the largest and most ancient
protein superfamilies found in all living organisms. They function as molecular machines by …

Cancer cell resistance to chemotherapy is often mediated by overexpression of P-
glycoprotein, a plasma membrane ABC (ATP-binding cassette) transporter which extrudes …

Viruses compete with each other for limited cellular resources, and some deliver defence
mechanisms that protect the host from competing genetic parasites. The phage …

Genomic instability in disease and its fidelity in health depend on the DNA damage
response (DDR), regulated in part from the complex of meiotic recombination 11 homolog 1 …

Structural maintenance of chromosomes (SMC) complexes organize genome topology in all
kingdoms of life and have been proposed to perform this function by DNA loop extrusion …

Tumor microbiota can produce active metabolites that affect cancer and immune cell
signaling, metabolism, and proliferation. Here, we explore tumor and gut microbiome …

All living organisms depend on primary and secondary membrane transport for the supply of
external nutrients and removal or sequestration of unwanted (toxic) compounds. Due to the …

Bacteria and their viruses (bacteriophages or phages) are engaged in an intense
evolutionary arms race,,,–. While the mechanisms of many bacterial antiphage defence …

DNA double-strand breaks (DSBs) are cytotoxic lesions that can result in mutagenic events
or cell death if left unrepaired or repaired inappropriately. Cells use two major pathways for …