Pyrrolizidine alkaloids: biosynthesis, biological activities and occurrence in crop plants
Pyrrolizidine alkaloids (PAs) are heterocyclic secondary metabolites with a typical
pyrrolizidine motif predominantly produced by plants as defense chemicals against …
pyrrolizidine motif predominantly produced by plants as defense chemicals against …
Sugar-mimic glycosidase inhibitors: natural occurrence, biological activity and prospects for therapeutic application
Alkaloids mimicking the structures of monosaccharides are now believed to be widespread
in plants and microorganisms, and these sugar mimics inhibit glycosidases because of a …
in plants and microorganisms, and these sugar mimics inhibit glycosidases because of a …
Polyhydroxylated alkaloids—natural occurrence and therapeutic applications
Over one hundred polyhydroxylated alkaloids have been isolated from plants and micro-
organisms. These alkaloids can be potent and highly selective glycosidase inhibitors and …
organisms. These alkaloids can be potent and highly selective glycosidase inhibitors and …
The amaryllidaceae alkaloids
O Hoshino - The alkaloids, 1998 - books.google.com
The Amaryllidaceae alkaloids have been isolated from the plants of almost all of the genera
of the family Amaryllidaceae and are members of the large group of isoquinoline alkaloids …
of the family Amaryllidaceae and are members of the large group of isoquinoline alkaloids …
Total syntheses of hyacinthacine A2 and 7-deoxycasuarine by cycloaddition to a carbohydrate derived nitrone
F Cardona, E Faggi, F Liguori, M Cacciarini, A Goti - Tetrahedron letters, 2003 - Elsevier
Practical syntheses of nitrone 8 by two different approaches from sugars are reported. Its use
as a versatile intermediate in highly selective 1, 3-dipolar cycloaddition reactions constitutes …
as a versatile intermediate in highly selective 1, 3-dipolar cycloaddition reactions constitutes …
Pyrrolizidine alkaloids
J Tamariz, E Burgueño-Tapia, MA Vázquez… - The alkaloids: chemistry …, 2018 - Elsevier
Naturally occurring pyrrolizidine alkaloids (PAs) are isolated from plants and other sources.
The interest of the scientific community in these compounds owes itself to their high toxicity …
The interest of the scientific community in these compounds owes itself to their high toxicity …
Recent advances in the total synthesis of piperidine azasugars
MSM Pearson, M Mathé‐Allainmat… - European journal of …, 2005 - Wiley Online Library
Since the discovery of nojirimycin, a glycosidase inhibitor, polyhydroxylated piperidines
(also called azasugars: the ring O‐atom of a carbohydrate is replaced by nitrogen) have …
(also called azasugars: the ring O‐atom of a carbohydrate is replaced by nitrogen) have …
Glycosidase inhibitors: a patent review (2008–2013)
Introduction: In the recent decades, the interest on glycosidases has dramatically increased,
mainly because these enzymes play a key role in many biological processes. The …
mainly because these enzymes play a key role in many biological processes. The …
Synthesis of polyhydroxylated pyrrolizidine alkaloids of the alexine family by tandem ring-closing metathesis− transannular cyclization.(+)-australine
JD White, P Hrnciar - The Journal of Organic Chemistry, 2000 - ACS Publications
Dienes 23 and 54, prepared from epoxy alcohol 9 via oxazolidinones 15 and 51,
respectively, underwent ring-closing metathesis with Grubbs's catalyst to give …
respectively, underwent ring-closing metathesis with Grubbs's catalyst to give …
Synthesis and biological activity of naturally occurring α-glucosidase inhibitors
DJ Wardrop, SL Waidyarachchi - Natural Product Reports, 2010 - pubs.rsc.org
Covering: 2005 to the end of 2009 In addition to their clinical importance in the treatment of
type II diabetes, α-glucosidase inhibitors have attracted considerable attention from the …
type II diabetes, α-glucosidase inhibitors have attracted considerable attention from the …