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Understanding the role of the perivascular space in cerebral small vessel disease
Small vessel diseases (SVDs) are a group of disorders that result from pathological
alteration of the small blood vessels in the brain, including the small arteries, capillaries and …
alteration of the small blood vessels in the brain, including the small arteries, capillaries and …
Advances in understanding the pathophysiology of lacunar stroke: a review
RW Regenhardt, AS Das, EH Lo, LR Caplan - JAMA neurology, 2018 - jamanetwork.com
Importance Stroke is the second leading cause of death in the world, and nearly one-third of
ischemic strokes are lacunar strokes (LSs) or small subcortical infarcts. Although smaller in …
ischemic strokes are lacunar strokes (LSs) or small subcortical infarcts. Although smaller in …
Clinical significance of magnetic resonance imaging markers of vascular brain injury: a systematic review and meta-analysis
Importance Covert vascular brain injury (VBI) is highly prevalent in community-dwelling
older persons, but its clinical and therapeutic implications are debated. Objective To better …
older persons, but its clinical and therapeutic implications are debated. Objective To better …
Genomics of perivascular space burden unravels early mechanisms of cerebral small vessel disease
Perivascular space (PVS) burden is an emerging, poorly understood, magnetic resonance
imaging marker of cerebral small vessel disease, a leading cause of stroke and dementia …
imaging marker of cerebral small vessel disease, a leading cause of stroke and dementia …
Cerebral small vessel disease genomics and its implications across the lifespan
M Sargurupremraj, H Suzuki, X Jian… - Nature …, 2020 - nature.com
White matter hyperintensities (WMH) are the most common brain-imaging feature of cerebral
small vessel disease (SVD), hypertension being the main known risk factor. Here, we …
small vessel disease (SVD), hypertension being the main known risk factor. Here, we …
Brain arteriolosclerosis
Abstract Brain arteriolosclerosis (B-ASC), characterized by pathologic arteriolar wall
thickening, is a common finding at autopsy in aged persons and is associated with cognitive …
thickening, is a common finding at autopsy in aged persons and is associated with cognitive …
[HTML][HTML] A vessel for change: endothelial dysfunction in cerebral small vessel disease
The blood vessels of the brain are lined with endothelial cells and it has been long known
that these help to regulate blood flow to the brain. However, there is increasing evidence …
that these help to regulate blood flow to the brain. However, there is increasing evidence …
Genetics of common cerebral small vessel disease
Cerebral small vessel disease (cSVD) is a leading cause of ischaemic and haemorrhagic
stroke and a major contributor to dementia. Covert cSVD, which is detectable with brain MRI …
stroke and a major contributor to dementia. Covert cSVD, which is detectable with brain MRI …
GWAS of multiple neuropathology endophenotypes identifies new risk loci and provides insights into the genetic risk of dementia
Genome-wide association studies (GWAS) have identified> 80 Alzheimer's disease and
related dementias (ADRD)-associated genetic loci. However, the clinical outcomes used in …
related dementias (ADRD)-associated genetic loci. However, the clinical outcomes used in …
Genetic basis of lacunar stroke: a pooled analysis of individual patient data and genome-wide association studies
M Traylor, E Persyn, L Tomppo, S Klasson… - The Lancet …, 2021 - thelancet.com
Background The genetic basis of lacunar stroke is poorly understood, with a single locus on
16q24 identified to date. We sought to identify novel associations and provide mechanistic …
16q24 identified to date. We sought to identify novel associations and provide mechanistic …