Complex biological systems and cellular networks may underlie most genotype to
phenotype relationships. Here, we review basic concepts in network biology, discussing …

A central goal of systems biology is to elucidate the structural and functional architecture of
the cell. To this end, large and complex networks of molecular interactions are being rapidly …

Praise for the first edition:… superb, beautifully written and organized work that takes an
engineering approach to systems biology. Alon provides nicely written appendices to …

Systematic map** of protein–protein interactions, or 'interactome'map**, was initiated in
model organisms, starting with defined biological processes, and then expanding to the …

Cytoscape is a free software package for visualizing, modeling and analyzing molecular and
genetic interaction networks. This protocol explains how to use Cytoscape to analyze the …

Various technologies can be used to produce genome-scale, or'omics', data sets that
provide systems-level measurements for virtually all types of cellular components in a model …

Many cancer-associated genes remain to be identified to clarify the underlying molecular
mechanisms of cancer susceptibility and progression. Better understanding is also required …

The execution of complex biological processes requires the precise interaction and
regulation of thousands of molecules. Systematic approaches to study large numbers of …

Motivation: Identification of functional modules in protein interaction networks is a first step in
understanding the organization and dynamics of cell functions. To ensure that the identified …

Molecular networks represent the backbone of molecular activity within the cell. Recent
studies have taken a comparative approach toward interpreting these networks, contrasting …