By gating the traffic of molecules and cells across the vessel wall, endothelial cells play a
central role in regulating cardiovascular functions and systemic homeostasis and in …

Melanoma is responsible for most skin cancer-associated deaths globally. The progression
of melanoma is influenced by a number of pathogenic processes. Understanding the …

Vascular endothelial growth factor‐C (VEGF‐C) binds to receptor vascular endothelial
growth factor receptor‐3 (VEGFR‐3) expressed on lymphatic endothelial and melanoma …

Despite being widely used for basic and preclinical studies in dermatology, available animal
models only partly recapitulate human skin features, often leading to disappointing outputs …

Although many solid tumors use the lymphatic system to metastasize, there are few
treatment options that directly target cancer present in the lymphatic system, and those that …

Ponatinib is a small molecule multi‐tyrosine kinase inhibitor clinically approved for
anticancer therapy. Molecular mechanisms by which cancer cells develop resistance …

The hepatocellular carcinoma (HCC) is the second most common cause of cancer deaths
worldwide. It occurs primarily as manifestation of other pathological processes, such as viral …

Simple Summary Mutations in NRAS are the second most common driver mutation in
melanoma and lack therapy options. We discovered that p38 plays the role of a tumor …

Melanoma cells can switch between distinct gene expression profiles, resulting in
proliferative or invasive phenotypes. Signaling pathways involved in this switch were …

Melanoma metastasis signals dismal prognosis even with current checkpoint inhibitors.
Long noncoding RNAs (lncRNAs) regulate dynamic metastasis in several cancers, including …