Choline and betaine in health and disease

PM Ueland - Journal of inherited metabolic disease, 2011 - Springer
Choline is an essential nutrient, but is also formed by de novo synthesis. Choline and its
derivatives serve as components of structural lipoproteins, blood and membrane lipids, and …

Protein stabilization and enzyme activation in ionic liquids: specific ion effects

H Zhao - Journal of Chemical Technology & Biotechnology, 2016 - Wiley Online Library
There are still debates on whether the hydration of ions perturbs the water structure, and
what is the degree of such disturbance; therefore, the origin of the Hofmeister effect on …

The clinical significance of betaine, an osmolyte with a key role in methyl group metabolism

M Lever, S Slow - Clinical biochemistry, 2010 - Elsevier
Betaine is an essential osmolyte and source of methyl groups and comes from either the diet
or by the oxidation of choline. Its metabolism methylates homocysteine to methionine, also …

Overview of the stability of α-chymotrypsin in different solvent media

A Kumar, P Venkatesu - Chemical Reviews, 2012 - ACS Publications
1. INTRODUCTION The ability of amino acids to form a three-dimensional (3D) protein
structure is significantly interesting because it combines the aspects of biophysical …

Industrial production of the cell protectant ectoine: protection mechanisms, processes, and products

HJ Kunte, G Lentzen, E Galinski - Current Biotechnology, 2014 - opus4.kobv.de
Bacteria, Archaea and Eukarya can adapt to Saline environments by accumulating
compatible solutes in order to maintain an osmotic equilibrium. Compatible solutes are of …

Activity and stability of α-chymotrypsin in biocompatible ionic liquids: enzyme refolding by triethyl ammonium acetate

P Attri, P Venkatesu, A Kumar - Physical Chemistry Chemical Physics, 2011 - pubs.rsc.org
In view the of wide scope of structural information of biomolecules in biocompatible ionic
liquids (ILs) in various applications including chemical and biochemical, it is essential to …

Expanding the potential role of deep eutectic solvents toward facilitating the structural and thermal stability of α-chymotrypsin

N Yadav, K Bhakuni, M Bisht, I Bahadur… - ACS Sustainable …, 2020 - ACS Publications
Since the introduction of deep eutectic solvents (DESs), numerous reports have surfaced
describing its tunable properties and environmentally benign nature. Due to such favorable …

Does the stability of proteins in ionic liquids obey the Hofmeister series?

A Kumar, P Venkatesu - International journal of biological macromolecules, 2014 - Elsevier
Understanding the behavior of Hofmeister anions of ionic liquids (ILs) on protein stability
helps to shed light on how the anions interact with proteins in aqueous solution and is a long …

Unveiling the potential of deep eutectic solvents to improve the conformational and colloidal stability of immunoglobulin G antibodies

D Dhiman, ASC Marques, M Bisht, APM Tavares… - Green …, 2023 - pubs.rsc.org
Antibodies, such as immunoglobulin G (IgG), have a pivotal role as biopharmaceuticals
capable of treating a wide variety of diseases. However, IgG is a protein, hence, it can easily …

Influence of osmolytes and denaturants on the structure and enzyme activity of α-chymotrypsin

P Attri, P Venkatesu, MJ Lee - The Journal of Physical Chemistry …, 2010 - ACS Publications
Enzymes are very sensitive and highly complex systems, exhibiting a substantial degree of
structural variability in their folded state. In the presence of cosolvents, the fluctuations …