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Choline and betaine in health and disease
PM Ueland - Journal of inherited metabolic disease, 2011 - Springer
Choline is an essential nutrient, but is also formed by de novo synthesis. Choline and its
derivatives serve as components of structural lipoproteins, blood and membrane lipids, and …
derivatives serve as components of structural lipoproteins, blood and membrane lipids, and …
Protein stabilization and enzyme activation in ionic liquids: specific ion effects
H Zhao - Journal of Chemical Technology & Biotechnology, 2016 - Wiley Online Library
There are still debates on whether the hydration of ions perturbs the water structure, and
what is the degree of such disturbance; therefore, the origin of the Hofmeister effect on …
what is the degree of such disturbance; therefore, the origin of the Hofmeister effect on …
The clinical significance of betaine, an osmolyte with a key role in methyl group metabolism
M Lever, S Slow - Clinical biochemistry, 2010 - Elsevier
Betaine is an essential osmolyte and source of methyl groups and comes from either the diet
or by the oxidation of choline. Its metabolism methylates homocysteine to methionine, also …
or by the oxidation of choline. Its metabolism methylates homocysteine to methionine, also …
Overview of the stability of α-chymotrypsin in different solvent media
1. INTRODUCTION The ability of amino acids to form a three-dimensional (3D) protein
structure is significantly interesting because it combines the aspects of biophysical …
structure is significantly interesting because it combines the aspects of biophysical …
Industrial production of the cell protectant ectoine: protection mechanisms, processes, and products
Bacteria, Archaea and Eukarya can adapt to Saline environments by accumulating
compatible solutes in order to maintain an osmotic equilibrium. Compatible solutes are of …
compatible solutes in order to maintain an osmotic equilibrium. Compatible solutes are of …
Activity and stability of α-chymotrypsin in biocompatible ionic liquids: enzyme refolding by triethyl ammonium acetate
In view the of wide scope of structural information of biomolecules in biocompatible ionic
liquids (ILs) in various applications including chemical and biochemical, it is essential to …
liquids (ILs) in various applications including chemical and biochemical, it is essential to …
Expanding the potential role of deep eutectic solvents toward facilitating the structural and thermal stability of α-chymotrypsin
Since the introduction of deep eutectic solvents (DESs), numerous reports have surfaced
describing its tunable properties and environmentally benign nature. Due to such favorable …
describing its tunable properties and environmentally benign nature. Due to such favorable …
Does the stability of proteins in ionic liquids obey the Hofmeister series?
Understanding the behavior of Hofmeister anions of ionic liquids (ILs) on protein stability
helps to shed light on how the anions interact with proteins in aqueous solution and is a long …
helps to shed light on how the anions interact with proteins in aqueous solution and is a long …
Unveiling the potential of deep eutectic solvents to improve the conformational and colloidal stability of immunoglobulin G antibodies
Antibodies, such as immunoglobulin G (IgG), have a pivotal role as biopharmaceuticals
capable of treating a wide variety of diseases. However, IgG is a protein, hence, it can easily …
capable of treating a wide variety of diseases. However, IgG is a protein, hence, it can easily …
Influence of osmolytes and denaturants on the structure and enzyme activity of α-chymotrypsin
Enzymes are very sensitive and highly complex systems, exhibiting a substantial degree of
structural variability in their folded state. In the presence of cosolvents, the fluctuations …
structural variability in their folded state. In the presence of cosolvents, the fluctuations …