Loop dynamics and the evolution of enzyme activity
In the early 2000s, Tawfik presented his 'New View'on enzyme evolution, highlighting the
role of conformational plasticity in expanding the functional diversity of limited repertoires of …
role of conformational plasticity in expanding the functional diversity of limited repertoires of …
A three-ring circus: metabolism of the three proteogenic aromatic amino acids and their role in the health of plants and animals
Tyrosine, phenylalanine and tryptophan are the three aromatic amino acids (AAA) involved
in protein synthesis. These amino acids and their metabolism are linked to the synthesis of a …
in protein synthesis. These amino acids and their metabolism are linked to the synthesis of a …
Catalytic Versatility, Stability, and Evolution of the (βα)8-Barrel Enzyme Fold
R Sterner, B Höcker - Chemical Reviews, 2005 - ACS Publications
Natural evolution has yielded enzymes that catalyze virtually all metabolic reactions under
mild conditions with high specificities and enormous rate enhancements. 1 It has been a …
mild conditions with high specificities and enormous rate enhancements. 1 It has been a …
Biosynthesis of histidine
ME Winkler, S Ramos-Montañez - EcoSal Plus, 2009 - Am Soc Microbiol
The biosynthesis of histidine in Escherichia coli and Salmonella typhimurium has been an
important model system for the study of relationships between the flow of intermediates …
important model system for the study of relationships between the flow of intermediates …
Conformational Modulation of a Mobile Loop Controls Catalysis in the (βα)8-Barrel Enzyme of Histidine Biosynthesis HisF
E Hupfeld, S Schlee, JP Wurm, C Rajendran… - JACS Au, 2024 - ACS Publications
The overall significance of loop motions for enzymatic activity is generally accepted.
However, it has largely remained unclear whether and how such motions can control …
However, it has largely remained unclear whether and how such motions can control …
Mimicking enzyme evolution by generating new (βα)8-barrels from (βα)4-half-barrels
B Höcker, J Claren, R Sterner - Proceedings of the National …, 2004 - National Acad Sciences
Gene duplication and fusion events that multiply and link functional protein domains are
crucial mechanisms of enzyme evolution. The analysis of amino acid sequences and three …
crucial mechanisms of enzyme evolution. The analysis of amino acid sequences and three …
1-Amino-1-deoxy-D-fructose (“fructosamine”) and its derivatives
VV Mossine, TP Mawhinney - Advances in carbohydrate chemistry and …, 2010 - Elsevier
Fructosamine has long been considered as a key intermediate of the Maillard reaction,
which to a large extent is responsible for specific aroma, taste, and color formation in …
which to a large extent is responsible for specific aroma, taste, and color formation in …
Evolutionary convergence in the biosyntheses of the imidazole moieties of histidine and purines
Background The imidazole group is an ubiquitous chemical motif present in several key
types of biomolecules. It is a structural moiety of purines, and plays a central role in …
types of biomolecules. It is a structural moiety of purines, and plays a central role in …
Occurrence of a putative ancient‐like isomerase involved in histidine and tryptophan biosynthesis
F Barona‐Gómez, DA Hodgson - EMBO reports, 2003 - embopress.org
We report the occurrence of an isomerase with a putative (βα) 8‐barrel structure involved in
both histidine and trypto‐phan biosynthesis in Streptomyces coelicolor A3 (2) and …
both histidine and trypto‐phan biosynthesis in Streptomyces coelicolor A3 (2) and …
Complex Loop Dynamics Underpin Activity, Specificity, and Evolvability in the (βα)8 Barrel Enzymes of Histidine and Tryptophan Biosynthesis
Enzymes are conformationally dynamic, and their dynamical properties play an important
role in regulating their specificity and evolvability. In this context, substantial attention has …
role in regulating their specificity and evolvability. In this context, substantial attention has …