[HTML][HTML] Integrated multimodal cell atlas of Alzheimer's disease
Alzheimer's disease (AD) is the leading cause of dementia in older adults. Although AD
progression is characterized by stereotyped accumulation of proteinopathies, the affected …
progression is characterized by stereotyped accumulation of proteinopathies, the affected …
Dimension-agnostic and granularity-based spatially variable gene identification using BSP
Identifying spatially variable genes (SVGs) is critical in linking molecular cell functions with
tissue phenotypes. Spatially resolved transcriptomics captures cellular-level gene …
tissue phenotypes. Spatially resolved transcriptomics captures cellular-level gene …
Spatial Transcriptomics: Biotechnologies, Computational Tools, and Neuroscience Applications
Q Wang, H Zhu, L Deng, S Xu, W ** of single-cell and spatial transcriptomics data with transfer learning
Profiling spatial variations of cellular composition and transcriptomic characteristics is
important for understanding the physiology and pathology of tissues. Spatial transcriptomics …
important for understanding the physiology and pathology of tissues. Spatial transcriptomics …
pyPAGE: A framework for Addressing biases in gene-set enrichment analysis—A case study on Alzheimer's disease
Inferring the driving regulatory programs from comparative analysis of gene expression data
is a cornerstone of systems biology. Many computational frameworks were developed to …
is a cornerstone of systems biology. Many computational frameworks were developed to …
Stereo-seq of the prefrontal cortex in aging and Alzheimer's disease
Aging increases the risk for Alzheimer's disease (AD), driving pathological changes like
amyloid-β (Aβ) buildup, inflammation, and oxidative stress, especially in the prefrontal cortex …
amyloid-β (Aβ) buildup, inflammation, and oxidative stress, especially in the prefrontal cortex …
Gingival spatial analysis reveals geographic immunological variation in a microbiota-dependent and-independent manner
Y Jaber, A Sarusi-Portuguez, Y Netanely… - npj Biofilms and …, 2024 - nature.com
In mucosal barriers, tissue cells and leukocytes collaborate to form specialized niches that
support host-microbiome symbiosis. Understanding the spatial organization of these barriers …
support host-microbiome symbiosis. Understanding the spatial organization of these barriers …
Distinct transcriptomic responses to Aβ plaques, neurofibrillary tangles, and APOE in Alzheimer's disease
INTRODUCTION Omics studies have revealed that various brain cell types undergo
profound molecular changes in Alzheimer's disease (AD) but the spatial relationships with …
profound molecular changes in Alzheimer's disease (AD) but the spatial relationships with …