The tubular hypothesis of nephron filtration and diabetic kidney disease

V Vallon, SC Thomson - Nature Reviews Nephrology, 2020 - nature.com
Kidney size and glomerular filtration rate (GFR) often increase with the onset of diabetes,
and elevated GFR is a risk factor for the development of diabetic kidney disease …

Pathophysiologic mechanisms in diabetic kidney disease: A focus on current and future therapeutic targets

J Barrera‐Chimal, F Jaisser - Diabetes, Obesity and …, 2020 - Wiley Online Library
Diabetic kidney disease (DKD) is the primary cause of chronic kidney disease around the
globe and is one of the main complications in patients with type 1 and 2 diabetes. The …

Glucose transporters in the kidney in health and disease

V Vallon - Pflügers Archiv-European Journal of Physiology, 2020 - Springer
The kidneys filter large amounts of glucose. To prevent the loss of this valuable fuel, the
tubular system of the kidney, particularly the proximal tubule, has been programmed to …

A guide to targeting the endocannabinoid system in drug design

A Stasiulewicz, K Znajdek, M Grudzień… - International journal of …, 2020 - mdpi.com
The endocannabinoid system (ECS) is one of the most crucial systems in the human
organism, exhibiting multi-purpose regulatory character. It is engaged in a vast array of …

Mitochondria in diabetic kidney disease

AA Ahmad, SO Draves, M Rosca - Cells, 2021 - mdpi.com
Diabetic kidney disease (DKD) is the leading cause of end stage renal disease (ESRD) in
the USA. The pathogenesis of DKD is multifactorial and involves activation of multiple …

[HTML][HTML] The therapeutic potential of second and third generation CB1R antagonists

R Cinar, MR Iyer, G Kunos - Pharmacology & therapeutics, 2020 - Elsevier
Endocannabinoids acting via CB 1 receptors (CB 1 R) play a critical role in regulating
energy homeostasis, which was the rationale for the pharmaceutical development of CB 1 R …

[HTML][HTML] Geniposide improves diabetic nephropathy by enhancing ULK1-mediated autophagy and reducing oxidative stress through AMPK activation

T Dusabimana, EJ Park, J Je, K Jeong, SP Yun… - International journal of …, 2021 - mdpi.com
Diabetic nephropathy (DN) is a common pathological feature in patients with diabetes and
the leading cause of end-stage renal disease. Although several pharmacological agents …

Multiple endocannabinoid-mediated mechanisms in the regulation of energy homeostasis in brain and peripheral tissues

I Ruiz de Azua, B Lutz - Cellular and molecular life sciences, 2019 - Springer
The endocannabinoid (eCB) system is widely expressed in many central and peripheral
tissues, and is involved in a plethora of physiological processes. Among these, activity of the …

[HTML][HTML] p-Coumaric Acid Nanoparticles Ameliorate Diabetic Nephropathy via Regulating mRNA Expression of KIM-1 and GLUT-2 in Streptozotocin-Induced Diabetic …

A Venkatesan, A Roy, S Kulandaivel, V Natesan… - Metabolites, 2022 - mdpi.com
Diabetic nephropathy (DN) has become a leading cause of end-stage renal failure
worldwide. The goal of the current study was to examine the protective effects of chitosan …

[HTML][HTML] The nephrologist's guide to cannabis and cannabinoids

JL Rein - Current opinion in nephrology and hypertension, 2020 - journals.lww.com
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