[HTML][HTML] Implication of trimethylamine N-oxide (TMAO) in disease: potential biomarker or new therapeutic target

MH Janeiro, MJ Ramírez, FI Milagro, JA Martínez… - Nutrients, 2018 - mdpi.com
Trimethylamine N-oxide (TMAO) is a molecule generated from choline, betaine, and
carnitine via gut microbial metabolism. The plasma level of TMAO is determined by several …

Gut microbiota-dependent marker TMAO in promoting cardiovascular disease: inflammation mechanism, clinical prognostic, and potential as a therapeutic target

S Yang, X Li, F Yang, R Zhao, X Pan, J Liang… - Frontiers in …, 2019 - frontiersin.org
Cardiovascular disease (CVD) is the leading cause of death worldwide, especially in
developed countries, and atherosclerosis (AS) is the common pathological basis of many …

Trimethylamine-N-oxide promotes age-related vascular oxidative stress and endothelial dysfunction in mice and healthy humans

VE Brunt, RA Gioscia-Ryan, AG Casso… - …, 2020 - ahajournals.org
Age-related vascular endothelial dysfunction is a major antecedent to cardiovascular
diseases. We investigated whether increased circulating levels of the gut microbiome …

Total volatile basic nitrogen and trimethylamine in muscle foods: Potential formation pathways and effects on human health

AEDA Bekhit, SG Giteru, BWB Holman… - … Reviews in Food …, 2021 - Wiley Online Library
The use of total volatile basic nitrogen (TVB‐N) as a quality parameter for fish is rapidly
growing to include other types of meat. Investigations of meat quality have recently focused …

Gut microbiota-dependent metabolite trimethylamine N-oxide contributes to cardiac dysfunction in western diet-induced obese mice

K Chen, X Zheng, M Feng, D Li, H Zhang - Frontiers in physiology, 2017 - frontiersin.org
Excessive consumption of diets high in sugars and saturated fat, frequently known as
western diet (WD), may lead to obesity and metabolic syndrome. Recent evidence shows …

Relationship of serum trimethylamine N-oxide (TMAO) levels with early atherosclerosis in humans

E Randrianarisoa, A Lehn-Stefan, X Wang, M Hoene… - Scientific reports, 2016 - nature.com
Abstract Circulating trimethylamine N-Oxide (TMAO) levels predict cardiovascular disease
(CVD), possibly by impacting on cholesterol metabolism and oxidative stress. Because …

The gut microbiome–derived metabolite trimethylamine N-oxide modulates neuroinflammation and cognitive function with aging

VE Brunt, TJ LaRocca, AE Bazzoni, ZJ Sapinsley… - GeroScience, 2021 - Springer
Aging is associated with declines in cognitive performance, which are mediated in part by
neuroinflammation, characterized by astrocyte activation and higher levels of pro …

The role of a gut microbial-derived metabolite, trimethylamine N-oxide (TMAO), in neurological disorders

SS Praveenraj, S Sonali, N Anand, HA Tousif… - Molecular …, 2022 - Springer
Trimethylamine lyases are expressed in a wide range of intestinal microbiota which
metabolize dietary nutrients like choline, betaine, and L-carnitine to form trimethylamine …

Trimethylamine N-oxide (TMAO), diet and cardiovascular disease

MS Thomas, ML Fernandez - Current atherosclerosis reports, 2021 - Springer
Abstract Purpose of Review The association between plasma Trimethylamine N-Oxide
(TMAO), diet and risk for cardiovascular disease (CVD) is still not fully understood. While …

[HTML][HTML] Gut Microbiota-Dependent Trimethylamine-N-oxide and Serum Biomarkers in Patients with T2DM and Advanced CKD

MAI Al-Obaide, R Singh, P Datta… - Journal of clinical …, 2017 - mdpi.com
Trimethylamine-N-oxide (TMAO) is a product of dietary, gut microbiome, and tissues
metabolism. Elevated blood TMAO levels are associated with heart attack, stroke and …