The interplay between chromatin, transcription factors and genes generates complex
regulatory circuits that can be represented as gene regulatory networks (GRNs). The study …

Uncovering the cis-regulatory code that governs when and how much each gene is
transcribed in a given genome and cellular state remains a central goal of biology. Here, we …

The emergence of drug resistance is the most substantial challenge to the effectiveness of
anticancer therapies. Orthogonal approaches have revealed that a subset of cells, known as …

Denoising diffusion models embody a type of generative artificial intelligence that can be
applied in computer vision, natural language processing and bioinformatics. In this Review …

Cis-regulatory elements (CREs) control gene expression, orchestrating tissue identity,
developmental timing and stimulus responses, which collectively define the thousands of …

Measurements of gene expression or signal transduction activity are conventionally
performed using methods that require either the destruction or live imaging of a biological …

Most mammalian genes have multiple polyA sites, representing a substantial source of
transcript diversity regulated by the cleavage and polyadenylation (CPA) machinery. To …

Aspirations for high crop growth and yield, nutritional quality and bioproduction of materials
are challenged by climate change and limited adoption of new technologies. Here, we …

The inability to scalably and precisely measure the activity of developmental cis-regulatory
elements (CREs) in multicellular systems is a bottleneck in genomics. Here we develop a …

Although the majority of annotated new genes in a given genome appear to have arisen
from duplication-related mechanisms, recent studies have shown that genes can also …