Neurodegenerative diseases are characterized by progressive cell loss leading to disruption
of the structure and function of the central nervous system. Amyotrophic lateral sclerosis …

Neuroinflammation is a complex biological process that plays a significant role in various
brain disorders. Microglia and astrocytes are the key cell types involved in inflammatory …

In vitro models of the human blood–brain barrier (BBB) are increasingly used to develop
therapeutics that can cross the BBB for treating diseases of the central nervous system. Here …

SNCA, the first gene associated with Parkinson's disease, encodes the α-synuclein protein,
the predominant component within pathological inclusions termed Lewy bodies. The …

The generation of astrocytes from human induced pluripotent stem cells has been hampered
by either prolonged differentiation—spanning over two months—or by shorter protocols that …

Induced pluripotent stem cell (iPSC)-based disease modeling has a great potential for
uncovering the mechanisms of pathogenesis, especially in the case of neurodegenerative …

Reprogramming of somatic cells into induced pluripotent stem cells (iPSCs) and their
differentiation into neural lineages is a revolutionary experimental system for studying …

Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system
(CNS) that affects about 2.5 million people worldwide. In MS, the patients' immune system …

In the brain, the complement system plays a crucial role in the immune response and in
synaptic elimination during normal development and disease. Here, we sought to identify …

Oligodendrocytes (OLs) are key players in the central nervous system, critical for the
formation and maintenance of the myelin sheaths insulating axons, ensuring efficient …