Infertility affects one in six couples worldwide, and fertility continues to deteriorate globally,
partly owing to a decline in semen quality. Sperm analysis has a central role in diagnosing …

Reproduction is an energy demanding function and only take place in case of sufficient
available energy status in mammals. Metabolic diseases such as anorexia nervosa are …

Uniparental inheritance of mitochondrial DNA (mtDNA) is an evolutionary trait found in
nearly all eukaryotes. In many species, including humans, the sperm mitochondria are …

Human sperm proteomics research has gained increasing attention lately, which provides
complete information about the functional state of the spermatozoa. Changes in the sperm …

Proteomic methodologies offer a robust approach to identify and quantify thousands of
proteins from semen components in both fertile donors and infertile patients. These …

Sperm cells are of unique elongated structure and function, the development of which is
tightly regulated by the existing proteins and the posttranslational modifications (PTM) of …

Research question Membrane lipid replacement (MLR) of oxidized membrane lipids can
restore sperm cellular membrane functionality and help improve surface protein stability …

Mammalian spermatozoa are not mature after ejaculation and must undergo additional
functional and structural changes within female reproductive tracts to achieve subsequent …

Background The cellular and molecular mechanisms of the events that help spermatozoa
acquire their fertilizing capability during capacitation and acrosome reaction are not …

An advanced understanding of sperm function is relevant for evidence-based male fertility
prediction and addressing male infertility. A standard breeding soundness evaluation (BSE) …