Insulin resistance, defined as a defect in insulin-mediated control of glucose metabolism in
tissues—prominently in muscle, fat and liver—is one of the earliest manifestations of a …

The consumption of Western-type calorically rich diets combined with chronic overnutrition
and a sedentary lifestyle in Western societies evokes a state of chronic metabolic …

The prevalence of obesity has increased worldwide in the past~ 50 years, reaching
pandemic levels. Obesity represents a major health challenge because it substantially …

The discovery of leptin changed the view of adipose tissue from that of a passive vessel that
stores fat to that of a dynamic endocrine organ that actively regulates behaviour and …

Peptide therapeutics have played a notable role in medical practice since the advent of
insulin therapy in the 1920s. Over 60 peptide drugs are approved in the United States and …

More than one-third of the worldwide population is overweight or obese and therefore at risk
of develo** type 2 diabetes mellitus. In order to mitigate this pandemic, safer and more …

The gut is now recognized as a major regulator of motivational and emotional states.
However, the relevant gut-brain neuronal circuitry remains unknown. We show that optical …

The gastrointestinal tract has recently come to the forefront of multiple research fields. It is
now recognized as a major source of signals modulating food intake, insulin secretion and …

Under homeostatic conditions, animals use well-defined hypothalamic neural circuits to help
maintain stable body weight, by integrating metabolic and hormonal signals from the …

More than one-third of adults in the USA have obesity, which causes, exacerbates or
adversely impacts numerous medical comorbidities, including diabetes mellitus and …