[HTML][HTML] A cytokine-mediated link between innate immunity, inflammation, and cancer
WW Lin, M Karin - The Journal of clinical investigation, 2007 - Am Soc Clin Investig
It has been established that cancer can be promoted and/or exacerbated by inflammation
and infections. Indeed, chronic inflammation orchestrates a tumor-supporting …
and infections. Indeed, chronic inflammation orchestrates a tumor-supporting …
Lipid rafts as major platforms for signaling regulation in cancer
Cell signaling does not apparently occur randomly over the cell surface, but it seems to be
integrated very often into cholesterol-rich membrane domains, termed lipid rafts. Membrane …
integrated very often into cholesterol-rich membrane domains, termed lipid rafts. Membrane …
Galectin-3 is required for resident microglia activation and proliferation in response to ischemic injury
M Lalancette-Hébert, V Swarup… - Journal of …, 2012 - Soc Neuroscience
Growing evidence suggests that galectin-3 is involved in fine tuning of the inflammatory
responses at the periphery, however, its role in injured brain is far less clear. Our previous …
responses at the periphery, however, its role in injured brain is far less clear. Our previous …
Bone marrow microenvironment and the identification of new targets for myeloma therapy
K Podar, D Chauhan, KC Anderson - Leukemia, 2009 - nature.com
The development of multiple myeloma (MM) is a complex multi-step process involving both
early and late genetic changes in the tumor cell as well as selective supportive conditions by …
early and late genetic changes in the tumor cell as well as selective supportive conditions by …
[HTML][HTML] STATs: an old story, yet mesmerizing
Signal transducers and activators of transcription (STATs) are cytoplasmic transcription
factors that have a key role in cell fate. STATs, a protein family comprised of seven members …
factors that have a key role in cell fate. STATs, a protein family comprised of seven members …
Ursolic acid inhibits STAT3 activation pathway leading to suppression of proliferation and chemosensitization of human multiple myeloma cells
The activation of signal transducers and activators of transcription 3 (STAT3) has been
linked with the proliferation of a variety of human cancer cells, including multiple myeloma …
linked with the proliferation of a variety of human cancer cells, including multiple myeloma …
Paradoxical effects of cytokines in tumor immune surveillance and tumor immune escape
The role of cytokines in modulating the formation of new tumors is mediated by their ability to
regulate antigen-specific anti-tumor responses and by the activation of non-specific …
regulate antigen-specific anti-tumor responses and by the activation of non-specific …
Monoclonal antibodies for the treatment of multiple myeloma: an update
HN Abramson - International Journal of Molecular Sciences, 2018 - mdpi.com
The past two decades have seen a revolution in multiple myeloma (MM) therapy with the
introduction of several small molecules, mostly orally effective, whose mechanisms are …
introduction of several small molecules, mostly orally effective, whose mechanisms are …
The role of IGF-1 as a major growth factor for myeloma cell lines and the prognostic relevance of the expression of its receptor
AC Sprynski, D Hose, L Caillot, T Réme… - Blood, The Journal …, 2009 - ashpublications.org
A plethora of myeloma growth factors (MGFs) has been identified, but their relative
importance and cooperation have not been determined. We investigated 5 MGFs …
importance and cooperation have not been determined. We investigated 5 MGFs …
IGF1-mediated human embryonic stem cell self-renewal recapitulates the embryonic niche
Our understanding of the signalling pathways regulating early human development is
limited, despite their fundamental biological importance. Here, we mine transcriptomics …
limited, despite their fundamental biological importance. Here, we mine transcriptomics …