The most problematic issue in clinical nephrology is the relentless and progressive increase
in patients with ESRD (end-stage renal disease) worldwide. The impact of diabetic …

Monocyte Chemoattractant Protein-1 (MCP-1) is the first discovered and most extensively
studied CC chemokine, and the amount of studies on its role in the etiologies of obesity-and …

Diabetic nephropathy is the leading cause of end‐stage kidney disease worldwide but
current treatments remain suboptimal. This review examines the evidence for inflammation …

BACKGROUND: Monocyte Chemoattractant Protein (MCP)-1, a potent monocyte attractant,
is a member of the CC chemokine subfamily. MCP-1 exerts its effects through binding to G …

Angiotensin II (AngII), the major effector peptide of renin–angiotensin system (RAS), is now
recognized as a growth factor that regulates cell growth and fibrosis, besides being a …

Diabetes mellitus is known to trigger retinopathy, neuropathy and nephropathy. Diabetic
nephropathy, a long-term major microvascular complication of uncontrolled hyperglycemia …

Background. Nuclear factor-κB (NF-κB) regulates genes involved in renal disease
progression, such as the chemokines monocyte chemoattractant protein-1 (MCP-1) and …

Diabetic nephropathy involves a renal inflammatory response induced by the diabetic
milieu. Macrophages accumulate in diabetic kidneys in association with the local …

Many experimental data have suggested that the renin-angiotensin system participates in
immune and inflammatory responses. Angiotensin II is involved in several steps of the …

Background: Diabetic nephropathy is a major global health problem. Progression to renal
failure is common; however, the mechanisms are unknown. Experimental models suggest a …