Advancements and challenges in brain cancer therapeutics

F Bai, Y Deng, L Li, M Lv, J Razzokov, Q Xu, Z Xu… - …, 2024 - Wiley Online Library
Treating brain tumors requires a nuanced understanding of the brain, a vital and delicate
organ. Location, size, tumor type, and surrounding tissue health are crucial in develo** …

[PDF][PDF] Modern radiation therapy for the management of brain metastases from non-small cell lung cancer: current approaches and future directions

C Mantovani, A Gastino, M Cerrato, S Badellino… - Frontiers in …, 2021 - frontiersin.org
Brain metastases (BMs) represent the most frequent event during the course of Non-Small
Cell Lung Cancer (NSCLC) disease. Recent advancements in the diagnostic and …

Whole-brain irradiation with hippocampal sparing and dose escalation on metastases: neurocognitive testing and biological imaging (HIPPORAD)–a phase II …

AL Grosu, L Frings, I Bentsalo, O Oehlke, F Brenner… - BMC cancer, 2020 - Springer
Background Whole brain radiation therapy (WBRT) is the standard therapy for multiple brain
metastases. However, WBRT has a poor local tumor control and is associated with a decline …

Novel mechanisms and future opportunities for the management of radiation necrosis in patients treated for brain metastases in the era of immunotherapy

EJ Vaios, SF Winter, HA Shih, J Dietrich, KB Peters… - Cancers, 2023 - mdpi.com
Simple Summary As the incidence and survival of patients with brain metastases improve,
the burden of treatment-related neurotoxicities will increase for patients and healthcare …

PRO: Do we still need whole-brain irradiation for brain metastases?

I Popp, NE Hartong, C Nieder, AL Grosu - Cancers, 2023 - mdpi.com
Simple Summary Whole-brain radiation therapy (WBRT) has been a mainstay in the
treatment of multiple cerebral metastases for many decades. However, evidence of its …

Hippocampus-avoidance whole-brain radiation therapy is efficient in the long-term preservation of hippocampal volume

I Popp, A Rau, E Kellner, M Reisert, JT Fennell… - Frontiers in …, 2021 - frontiersin.org
Background and Purpose With improved life expectancy, preventing neurocognitive decline
after cerebral radiotherapy is gaining more importance. Hippocampal damage has been …

Efficacy of whole-brain radiotherapy plus simultaneous integrated boost (SIB-WBRT) for lung cancer brain metastases

Q Bi, J Shen, P Li, Y Zeng, X Lian… - Journal of Cancer, 2024 - pmc.ncbi.nlm.nih.gov
Objective: To investigate the outcomes of SIB-WBRT in patients with brain metastases and
analyze the impact of some factors on prognosis. Materials and Methods: This single-arm …

Advances in radiotherapy for brain metastases

JK Matsui, HK Perlow, R Upadhyay… - Surgical Oncology …, 2023 - surgonc.theclinics.com
Brain metastases are the most common central nervous system (CNS) tumor in the adult
population and are projected to increase in incidence as survival outcomes improve for …

Hippocampal avoidance in whole brain radiotherapy and prophylactic cranial irradiation: a systematic review and meta-analysis

S Leskinen, HA Shah, B Yaffe, SJ Schneider… - Journal of Neuro …, 2023 - Springer
Purpose We systematically reviewed the current landscape of hippocampal-avoidance
radiotherapy, focusing specifically on rates of hippocampal tumor recurrence and changes …

Automated contouring and planning pipeline for hippocampal-avoidant whole-brain radiotherapy

CH Feng, M Cornell, KL Moore, R Karunamuni… - Radiation …, 2020 - Springer
Background Whole-brain radiotherapy (WBRT) remains an important treatment for over
200,000 cancer patients in the United States annually. Hippocampal-avoidant WBRT (HA …