This white paper discusses prospects for advancing hyperpolarization technology to better
understand cancer metabolism, identify current obstacles to HP (hyperpolarized) 13 C …

The study of transient chemical phenomena by conventional NMR has proved elusive,
particularly for non-1H nuclei. For 13C, hyperpolarization using the dynamic nuclear …

This first-in-man imaging study evaluated the safety and feasibility of hyperpolarized [1-13C]
pyruvate as an agent for noninvasively characterizing alterations in tumor metabolism for …

A major challenge in cancer biology is to monitor and understand cancer metabolism in vivo
with the goal of improved diagnosis and perhaps therapy. Because of the complexity of …

This review focuses on MRI contrast agents that are responsive to a change in a
physiological biomarker. The response mechanisms are dependent on six physicochemical …

Widespread prostate-specific antigen (PSA)–based screening and aggressive treatment of
prostate cancer have reduced mortality rates substantially, but both remain controversial in …

Non-invasive 13C magnetic resonance spectroscopy measurements of the uptake and
subsequent metabolism of 13C-labeled substrates is a powerful method for studying …

Dynamic nuclear polarization is an emerging technique for increasing the sensitivity of
magnetic resonance imaging and spectroscopy, particularly for low‐γ nuclei. The technique …

The reliance of many cancers on aerobic glycolysis has stimulated efforts to develop lactate
dehydrogenase (LDH) inhibitors. However, despite significant efforts, LDH inhibitors (LDHi) …

Abstract Metabolic imaging with hyperpolarized [1‐13C] pyruvate offers the unique
opportunity for a minimally invasive detection of cellular metabolism. Efficient and robust …