Plant roots communicate with microbes in a sophisticated manner through chemical
communication within the rhizosphere, thereby leading to biofilm formation of beneficial …

Behaviours of complex biomolecular systems are often irreducible to the elementary
properties of their individual components. Explanatory and predictive mathematical models …

Reconstructed microbial metabolic networks facilitate a mechanistic description of the
genotype–phenotype relationship through the deployment of constraint-based …

A central goal of systems biology is to elucidate the structural and functional architecture of
the cell. To this end, large and complex networks of molecular interactions are being rapidly …

Gene regulatory networks have an important role in every process of life, including cell
differentiation, metabolism, the cell cycle and signal transduction. By understanding the …

The availability and utility of genome‐scale metabolic reconstructions have exploded since
the first genome‐scale reconstruction was published a decade ago. Reconstructions have …

An increasing number of industrial bioprocesses capitalize on living cells by using them as
cell factories that convert sugars into chemicals. These processes range from the production …

Abstract Systems analysis of metabolic and growth functions in microbial organisms is
rapidly develo** and maturing. Such studies are enabled by reconstruction, at the …

Genome sequences are now available that enable us to determine the biological
components that make up a cell or an organism. The discipline of systems biology examines …

Prediction of metabolic changes that result from genetic or environmental perturbations has
several important applications, including diagnosing metabolic disorders and discovering …