Aging is characterized by systemic chronic inflammation, which is accompanied by cellular
senescence, immunosenescence, organ dysfunction, and age-related diseases. Given the …

During aging the immune system (IS) undergoes remarkable changes that collectively are
known as immunosenescence. It is a multifactorial and dynamic phenomenon that affects …

Aging is accompanied by remodeling of the immune system. With time, this leads to a
decline in immune efficacy, resulting in increased vulnerability to infectious diseases …

Aging leads to numerous changes that affect all physiological systems of the body including
the immune system, causing greater susceptibility to infectious disease and contributing to …

Major advances in preventing, delaying, or curing individual pathologies are responsible for
an increasingly long life span in the developed parts of our planet, and indeed reaching …

For many cancer types, incidence rises rapidly with age as an apparent power law,
supporting the idea that cancer is caused by a gradual accumulation of genetic mutations …

As is apparent from the many contributions to this Special Issue of the Journal, the impact of
age on immunity is nefarious, with all manner of dysregulated responses attributed to …

Age-related regression of the thymus is associated with a decline in naïve T cell output. This
is thought to contribute to the reduction in T cell diversity seen in older individuals and linked …

Restricting the intake of calories has been practiced as a method for increasing both the
length and quality of life for over 500years. Experimental work confirming the success of this …

Cellular senescence is induced by stresses and results in a stable proliferation arrest
accompanied by a pro-inflammatory secretome. Senescent cells accumulate during aging …