Dendritic spines: Revisiting the physiological role
Dendritic spines are small, thin, specialized protrusions from neuronal dendrites, primarily
localized in the excitatory synapses. Sophisticated imaging techniques revealed that …
localized in the excitatory synapses. Sophisticated imaging techniques revealed that …
Dendritic spine dysgenesis in autism related disorders
The activity-dependent structural and functional plasticity of dendritic spines has led to the
long-standing belief that these neuronal compartments are the subcellular sites of learning …
long-standing belief that these neuronal compartments are the subcellular sites of learning …
Trofinetide for the treatment of Rett syndrome: a randomized phase 3 study
Rett syndrome is a rare, genetic neurodevelopmental disorder. Trofinetide is a synthetic
analog of glycine–proline–glutamate, the N-terminal tripeptide of the insulin-like growth …
analog of glycine–proline–glutamate, the N-terminal tripeptide of the insulin-like growth …
Mitigation of honokiol on fluoride-induced mitochondrial oxidative stress, mitochondrial dysfunction, and cognitive deficits through activating AMPK/PGC-1α/Sirt3
D Wang, L Cao, X Zhou, G Wang, Y Ma, X Hao… - Journal of hazardous …, 2022 - Elsevier
Oxidative stress and mitochondrial dysfunction contribute greatly to fluoride-induced
cognitive impairment and behavioural disorders. Honokiol, a natural biphenolic compound …
cognitive impairment and behavioural disorders. Honokiol, a natural biphenolic compound …
International STakeholder NETwork (ISTNET): creating a developmental neurotoxicity (DNT) testing road map for regulatory purposes
A major problem in developmental neurotoxicity (DNT) risk assessment is the lack of
toxicological hazard information for most compounds. Therefore, new approaches are being …
toxicological hazard information for most compounds. Therefore, new approaches are being …
Molecular regulation of dendritic spine dynamics and their potential impact on synaptic plasticity and neurological diseases
P Maiti, J Manna, G Ilavazhagan, J Rossignol… - Neuroscience & …, 2015 - Elsevier
The structure and dynamics of dendritic spines reflect the strength of synapses, which are
severely affected in different brain diseases. Therefore, understanding the ultra-structure …
severely affected in different brain diseases. Therefore, understanding the ultra-structure …
BDNF impact on synaptic dynamics: extra or intracellular long-term release differently regulates cultured hippocampal synapses
Abstract Brain Derived Neurotrophic Factor (BDNF) signalling contributes to the formation,
maturation and plasticity of Central Nervous System (CNS) synapses. Acute exposure of …
maturation and plasticity of Central Nervous System (CNS) synapses. Acute exposure of …
Photobiomodulation improves the synapses and cognitive function and ameliorates epileptic seizure by inhibiting downregulation of Nlgn3
Background Temporal lobe epilepsy (TLE) remains one of the most drug-resistant focal
epilepsies. Glutamate excitotoxicity and neuroinflammation which leads to loss of synaptic …
epilepsies. Glutamate excitotoxicity and neuroinflammation which leads to loss of synaptic …
A subset of autism-associated genes regulate the structural stability of neurons
Autism spectrum disorder (ASD) comprises a range of neurological conditions that affect
individuals' ability to communicate and interact with others. People with ASD often exhibit …
individuals' ability to communicate and interact with others. People with ASD often exhibit …
[HTML][HTML] Trofinetide for the treatment of Rett syndrome: results from the open-label extension LILAC study
Background Trofinetide was approved for the treatment of Rett syndrome based on the
results of the phase 3, randomized, placebo-controlled, 12-week LAVENDER study. Rett …
results of the phase 3, randomized, placebo-controlled, 12-week LAVENDER study. Rett …