PURPOSE The combination of whole-genome and transcriptome sequencing (WGTS) is
expected to transform diagnosis and treatment for patients with cancer. WGTS is a …

Hereditary cancer syndromes account for nearly 10% of cancers even though they are often
underdiagnosed. Finding a pathogenic gene variant could have dramatic implications in …

Abstract Analysis of selected cancer genes has become an important tool in precision
oncology but cannot fully capture the molecular features and, most importantly …

In the last decades, the development of high‐throughput molecular assays has
revolutionised cancer diagnostics, paving the way for the concept of personalised cancer …

Current precision cancer medicine is dependent on the analyses of a plethora of clinically
relevant genomic aberrations. During the last decade, next-generation sequencing (NGS) …

Several genetic investigations were conducted to identify germline and somatic mutations in
somatotropinomas, a subtype of pituitary tumors. To our knowledge, we report the first …

Background Patients with unfavorable carcinoma of unknown primary origin (CUP) have an
extremely poor prognosis of∼ 1 year or less, stressing the need for more tailored treatments …

Background For patients with metastatic rare cancers, treatments are limited. How
systematic tumor sequencing can improve therapeutic possibilities in this population …

Simple Summary Lynch syndrome (LS) stands as the predominant inherited cancer
condition at present. Currently, surveillance is based on genotype-driven strategies and …

Precision oncology offers new cancer treatment options, yet sequencing methods vary in
type and scope. In this study, we compared whole-exome/whole-genome (WES/WGS) and …