Recent advance in oxazole-based medicinal chemistry
HZ Zhang, ZL Zhao, CH Zhou - European journal of medicinal chemistry, 2018 - Elsevier
Oxazole compounds containing nitrogen and oxygen atoms in the five-membered aromatic
ring are readily able to bind with a variety of enzymes and receptors in biological systems …
ring are readily able to bind with a variety of enzymes and receptors in biological systems …
Recent advancement in the discovery and development of COX-2 inhibitors: Insight into biological activities and SAR studies (2008–2019)
Cyclooxygenase-2 is a very important physiological enzyme playing key roles in various
biological functions especially in the mechanism of pain and inflammation, among other …
biological functions especially in the mechanism of pain and inflammation, among other …
Theoretical investigations on the HOMO–LUMO gap and global reactivity descriptor studies, natural bond orbital, and nucleus-independent chemical shifts analyses of 3-phenylbenzo[d] …
Natural bond orbital analysis, salvation, and substituent effects of electron-releasing (–CH3,–
OH) and electron-withdrawing (–Cl,–NO2,–CF3) groups at para positions on the molecular …
OH) and electron-withdrawing (–Cl,–NO2,–CF3) groups at para positions on the molecular …
Recent advancements in the development of heterocyclic anti-inflammatory agents
Most of the anti-inflammatory drugs in clinical practice are becoming outdated owing to their
potential side and adverse effects. These are found to be highly unsafe for long term use …
potential side and adverse effects. These are found to be highly unsafe for long term use …
[HTML][HTML] Synthesis and characterization of different complexes derived from Schiff base and evaluation as a potential anticancer, antimicrobial, and insecticide agent
The condensation of (1H-benzimidazole-2-yl) methanamine, with 2-hydroxy
naphthaldehyde lead to Schiff base ligand (H2L)(1). This was later reacted with metal salts …
naphthaldehyde lead to Schiff base ligand (H2L)(1). This was later reacted with metal salts …
Pyrimidine and fused pyrimidine derivatives as promising protein kinase inhibitors for cancer treatment
Pyrimidine ring and its fused derivatives including pyrazolo [3, 4-d] pyrimidine, pyrido [2, 3-d]
pyrimidine, quinazoline, and furo [2, 3-d] pyrimidine compounds had received much interest …
pyrimidine, quinazoline, and furo [2, 3-d] pyrimidine compounds had received much interest …
Cyclooxygenase-2 (COX-2) as a target of anticancer agents: A review of novel synthesized scaffolds having anticancer and COX-2 inhibitory potentialities
Cancer is a serious threat to human beings and is the second-largest cause of death all over
the globe. Chemotherapy is one of the most common treatments for cancer; however, drug …
the globe. Chemotherapy is one of the most common treatments for cancer; however, drug …
Recent progress in anticancer agents incorporating pyrazole scaffold
S Mor, M Khatri, R Punia… - Mini Reviews in Medicinal …, 2022 - benthamdirect.com
The search for new anticancer agents is considered a dynamic field of medicinal chemistry.
In recent years, the synthesis of compounds with anticancer potential has increased and a …
In recent years, the synthesis of compounds with anticancer potential has increased and a …
Design and Development of COX-II Inhibitors: Current Scenario and Future Perspective
Innate inflammation beyond a threshold is a significant problem involved in cardiovascular
diseases, cancer, and many other chronic conditions. Cyclooxygenase (COX) enzymes are …
diseases, cancer, and many other chronic conditions. Cyclooxygenase (COX) enzymes are …
Environment-friendly and efficient synthesis of 2-aminobenzo-xazoles and 2-aminobenzothiazoles catalyzed by Vitreoscilla hemoglobin incorporating a cobalt …
Y Xu, F Li, N Zhao, J Su, C Wang, C Wang, Z Li… - Green …, 2021 - pubs.rsc.org
In this study, an environment-friendly and efficient artificial Vitreoscilla hemoglobin (VHb) for
the synthesis of 2-aminobenzoxazoles and 2-aminobenzothiazoles has been reported. We …
the synthesis of 2-aminobenzoxazoles and 2-aminobenzothiazoles has been reported. We …