The high mobility group A (HMGA) non-histone chromatin proteins alter chromatin structure
and thereby regulate the transcription of several genes by either enhancing or suppressing …

The high mobility group (HMG) proteins are a superfamily of abundant and ubiquitous
nuclear proteins that bind to DNA and nucleosomes and induce structural changes in the …

High mobility group A1 (HMGA1) chromatin regulators are upregulated in diverse tumors
where they portend adverse outcomes, although how they function in cancer remains …

The 'high mobility group'HMGA protein family consists of four members: HMGA1a, HMGA1b
and HMGA1c, which result from translation of alternative spliced forms of one gene and …

Although the three families of mammalian HMG proteins (HMGA, HMGB and HMGN)
participate in many of the same nuclear processes, each family plays its own unique role in …

MicroRNAs are subject to precise regulation and have key roles in tumorigenesis. In contrast
to the oncogenic role of miR-22 reported in myelodysplastic syndrome (MDS) and breast …

Mutated tumor cells undergo changes in chromatin accessibility and gene expression,
resulting in aberrant proliferation and differentiation, although how this occurs is unclear …

Introduction• Gene structure and regulation• Target molecules• Role in development• Role in
cancer• Other biological functions• Summary and perspectives The discovery of microRNAs …

The structural characteristics of the three nuclear phosphoproteins of the high mobility group
A family are outlined and related to their participation in chromatin structure alteration in …

Pancreatic cancer is a highly aggressive malignancy due to elevated mitotic activities and
epithelial-mesenchymal transition (EMT). Oncogenic RAS and transforming growth factor-β …