Infertility affects~ 7% of couples of reproductive age with little change in incidence in the last
two decades. ART, as well as other interventions, have made major strides in correcting this …

BACKGROUND In a growth phase occurring during most of folliculogenesis, the oocyte
produces and accumulates molecules and organelles that are fundamental for the …

The N 6-methyladenosine (m6A) modification is the most prevalent internal RNA
modification in eukaryotes. The majority of m6A sites are found in the last exon and 3'UTRs …

A central dogma of mammalian reproductive biology is that the size of the primordial follicle
pool represents reproductive capacity in females. The assembly of the primordial follicle …

Background Oocyte growth is accompanied by follicular development in mammalian
ovaries. Since the discovery of two oocyte‐derived factors, growth differentiation factor 9 …

Meiotic progression in mammalian preovulatory follicles is controlled by the granulosa cells
around the oocyte. Cyclic GMP (cGMP) generated in the granulosa cells diffuses through …

During the peri-ovulatory period, the gonadotropin LH triggers major changes in both the
somatic and germ cell compartments of the ovarian follicle. The oocyte completes the …

Mammalian oocytes grow and undergo meiosis within ovarian follicles. Oocytes are arrested
at the first meiotic prophase, held in meiotic arrest by the surrounding follicle cells until a …

The develo** fetus requires substantial amounts of fatty acids to support rapid cellular
growth and activity. Although the fatty acid composition delivered to the fetus is largely …

Successful ovulation requires that developmentally competent oocytes are released with
appropriate timing from the ovarian follicle. Somatic cells of the follicle sense the ovulatory …