IEGs play a critical functional role of in molecular, cellular, and behavioral alterations
induced by psychostimulants. IEGs appear to have specific chromatin structures that may …

The ubiquitously expressed serum and glucocorticoid regulated kinase 1 (SGK1) is tightly
regulated by osmotic and hormonal signals, including glucocorticoids and …

Neuronal ensembles in ventromedial prefrontal cortex (vmPFC) play a role in both cocaine
and palatable food seeking. However, it is unknown whether similar or different vmPFC …

Structural and functional changes of the brain are assumed to contribute to excessive
cocaine intake, craving, and relapse in cocaine use disorder (CUD). Epigenetic and …

Cocaine drastically elevates dopamine (DA) levels in the striatum, a brain region that is
critical to the psychomotor and rewarding properties of the drug. DA signaling regulates …

Epigenetic mechanisms have gained increasing attention as regulators of synaptic plasticity
and responsiveness to drugs of abuse. In particular, it has been shown that the activity of the …

Childhood malnutrition is a risk factor for mental disorders, such as major depression and
anxiety. Evidence shows that similar early life adversities induce sex-dependent epigenetic …

Addiction is associated with neuroadaptive changes in the brain. In the present paper, we
used a model of methamphetamine self-administration during which we used footshocks to …

E-cigarette use has been marketed as a safer alternative to traditional cigarettes, as a
means of smoking cessation, and are used at a higher rate than the general population in …

Drug addiction develops due to brain-wide plasticity within neuronal ensembles, mediated
by dynamic gene expression. Though the most common approach to identify such …