Epilepsy and brain network hubs

J Royer, BC Bernhardt, S Larivière, E Gleichgerrcht… - …, 2022 - Wiley Online Library
Epilepsy is a disorder of brain networks. A better understanding of structural and dynamic
network properties may improve epilepsy diagnosis, treatment, and prognostics. Hubs are …

[HTML][HTML] Recent advances in neuroimaging of epilepsy

AM Goodman, JP Szaflarski - Neurotherapeutics, 2021 - Elsevier
Human neuroimaging has had a major impact on the biological understanding of epilepsy
and the relationship between pathophysiology, seizure management, and outcomes. This …

Identification of different MRI atrophy progression trajectories in epilepsy by subtype and stage inference

F **ao, L Caciagli, B Wandschneider, D Sone… - Brain, 2023 - academic.oup.com
Artificial intelligence (AI)-based tools are widely employed, but their use for diagnosis and
prognosis of neurological disorders is still evolving. Here we analyse a cross-sectional …

Thalamic deep brain stimulation modulates cycles of seizure risk in epilepsy

NM Gregg, V Sladky, P Nejedly, F Mivalt, I Kim… - Scientific reports, 2021 - nature.com
Chronic brain recordings suggest that seizure risk is not uniform, but rather varies
systematically relative to daily (circadian) and multiday (multidien) cycles. Here, one human …

A shifting role of thalamocortical connectivity in the emergence of cortical functional organization

S Park, KV Haak, S Oldham, H Cho, K Byeon… - Nature …, 2024 - nature.com
The cortical patterning principle has been a long-standing question in neuroscience, yet
how this translates to macroscale functional specialization in the human brain remains …

Improving the prediction of epilepsy surgery outcomes using basic scalp EEG findings

Z Fitzgerald, M Morita‐Sherman, O Hogue… - …, 2021 - Wiley Online Library
Objective This study aims to evaluate the role of scalp electroencephalography (EEG; ictal
and interictal patterns) in predicting resective epilepsy surgery outcomes. We use the data to …

Focal to bilateral tonic–clonic seizures are associated with widespread network abnormality in temporal lobe epilepsy

N Sinha, N Peternell, GM Schroeder, J de Tisi… - …, 2021 - Wiley Online Library
Objective Our objective was to identify whether the whole‐brain structural network
alterations in patients with temporal lobe epilepsy (TLE) and focal to bilateral tonic–clonic …

Disorganization of language and working memory systems in frontal versus temporal lobe epilepsy

L Caciagli, C Paquola, X He, C Vollmar, M Centeno… - Brain, 2023 - academic.oup.com
Cognitive impairment is a common comorbidity of epilepsy and adversely impacts people
with both frontal lobe (FLE) and temporal lobe (TLE) epilepsy. While its neural substrates …

A phase 1 open‐label trial evaluating focused ultrasound unilateral anterior thalamotomy for focal onset epilepsy

V Krishna, J Mindel, F Sammartino, C Block… - …, 2023 - Wiley Online Library
Objective Focused ultrasound ablation (FUSA) is an emerging treatment for neurological
and psychiatric diseases. We describe the initial experience from a pilot, open‐label, single …

Episodic memory network connectivity in temporal lobe epilepsy

M Fleury, S Buck, LP Binding, L Caciagli, SB Vos… - …, 2022 - Wiley Online Library
Objective Temporal lobe epilepsy (TLE) affects brain networks and is associated with
impairment of episodic memory. Temporal and extratemporal reorganization of memory …