Obstructive sleep apnea syndrome (OSAS) is a common breathing disorder in sleep in
which the airways narrow or collapse during sleep, causing obstructive sleep apnea. The …

Intermittent hypoxia (IH) is a hallmark manifestation of obstructive sleep apnea (OSA), a
widespread disorder of breathing. This Review focuses on the role of hypoxia-inducible …

Oxygen homeostasis represents an organizing principle for understanding metazoan
evolution, development, physiology, and pathobiology. The hypoxia-inducible factors (HIFs) …

Sleep-induced apnea and disordered breathing refers to intermittent, cyclical cessations or
reductions of airflow, with or without obstructions of the upper airway (OSA). In the presence …

The carotid body (CB) is the main peripheral chemoreceptor for arterial respiratory gases O2
and CO2 and pH, eliciting reflex ventilatory, cardiovascular, and humoral responses to …

Obstructive sleep apnoea (OSA) is a common disorder in which repetitive apnoeas expose
the cardiovascular system to cycles of hypoxia, exaggerated negative intrathoracic pressure …

Rationale: Obstructive sleep apnea is a risk factor for mortality, but its diagnostic metric—the
apnea–hypopnea index—is a poor risk predictor. The apnea–hypopnea index does not …

Summary Approximately 70–85% of patients with resistant hypertension (RH) report
obstructive sleep apnea (OSA). However, whether therapy with continuous positive airway …

Background—Heart failure is a highly prevalent disorder that continues to be associated
with repeated hospitalizations, high morbidity, and high mortality. Sleep-related breathing …

Sleep apnea occurs in 5% to 10% of the general population, regardless of race and
ethnicity. 1 By contrast, in patients with cardiovascular diseases (CVDs), its prevalence …