Aurora kinases are serine/threonine kinases essential for the onset and progression of
mitosis. Aurora members share a similar protein structure and kinase activity, but exhibit …

It has become clear that the role of centrosomes extends well beyond that of important
microtubule organizers. There is increasing evidence that they also function as coordination …

Temporally and spatially controlled activation of the Aurora A kinase (AURKA) regulates
centrosome maturation, entry into mitosis, formation and function of the bipolar spindle, and …

The Aurora kinase family is comprised of three serine/threonine kinases, Aurora‐A, Aurora‐
B, and Aurora‐C. Among these, Aurora‐A and Aurora‐B play central roles in mitosis …

Neuroblastoma is the most common extracranial solid tumor of children. Neuroblastoma
tumors derive from the neural crest and synthesize neurotransmitters including the …

Protein interactions are involved in all cellular processes. Their efficient and reliable
characterization is therefore essential for understanding biological mechanisms. In this …

Fast growth of microtubules is essential for rapid assembly of the microtubule cytoskeleton
during cell proliferation and differentiation. XMAP215 belongs to a conserved family of …

Oocytes accumulate maternal stores (proteins, mRNAs, metabolites, etc.) during their growth
in the ovary to support development after fertilization. To preserve this cytoplasmic maternal …

The centrosome was discovered in the late 19th century when mitosis was first described.
Long recognized as a key organelle of the spindle pole, its core component, the centriole …

Nearly two decades ago, Xenopus oocytes were found to contain mRNAs harboring a small
sequence in their 3′ untranslated regions that control cytoplasmic polyadenylation and …