Blue-light receptors for optogenetics

A Losi, KH Gardner, A Möglich - Chemical reviews, 2018 - ACS Publications
Sensory photoreceptors underpin light-dependent adaptations of organismal physiology,
development, and behavior in nature. Adapted for optogenetics, sensory photoreceptors …

LOV-based optogenetic devices: light-driven modules to impart photoregulated control of cellular signaling

A Pudasaini, KK El-Arab, BD Zoltowski - Frontiers in molecular …, 2015 - frontiersin.org
The Light-Oxygen-Voltage domain family of proteins is widespread in biology where they
impart sensory responses to signal transduction domains. The small, light responsive LOV …

Function, structure and mechanism of bacterial photosensory LOV proteins

J Herrou, S Crosson - Nature reviews microbiology, 2011 - nature.com
LOV (light, oxygen or voltage) domains are protein photosensors that are conserved in
bacteria, archaea, plants and fungi, and detect blue light via a flavin cofactor. LOV domains …

The evolution of flavin-binding photoreceptors: an ancient chromophore serving trendy blue-light sensors

A Losi, W Gärtner - Annual review of plant biology, 2012 - annualreviews.org
Photoreceptor flavoproteins of the LOV, BLUF, and cryptochrome families are ubiquitous
among the three domains of life and are configured as UVA/blue-light systems not only in …

LOV to BLUF: flavoprotein contributions to the optogenetic toolkit

JM Christie, J Gawthorne, G Young, NJ Fraser, AJ Roe - Molecular plant, 2012 - cell.com
Optogenetics is an emerging field that combines optical and genetic approaches to non-
invasively interfere with cellular events with exquisite spatiotemporal control. Although it …

Old Chromophores, New Photoactivation Paradigms, Trendy Applications: Flavins in Blue Light‐Sensing Photoreceptors

A Losi, W Gärtner - Photochemistry and photobiology, 2011 - Wiley Online Library
The knowledge on the mechanisms by which blue light (BL) is sensed by diverse and
numerous organisms, and of the physiological responses elicited by the BL photoreceptors …

Rational design of an efficient, genetically encodable, protein-encased singlet oxygen photosensitizer

M Westberg, L Holmegaard, FM Pimenta… - Journal of the …, 2015 - ACS Publications
Singlet oxygen, O2 (a1Δg), plays a key role in many processes of cell signaling. Limitations
in mechanistic studies of such processes are generally associated with the difficulty of …

Optogenetic control of cell function using engineered photoreceptors

GP Pathak, JD Vrana, CL Tucker - Biology of the Cell, 2013 - Wiley Online Library
Over the past decades, there has been growing recognition that light can provide a powerful
stimulus for biological interrogation. Light‐actuated tools allow manipulation of molecular …

Structure and function of the ZTL/FKF1/LKP2 group proteins in Arabidopsis

BD Zoltowski, T Imaizumi - The Enzymes, 2014 - Elsevier
Abstract The ZTL/FKF1/LKP2 group proteins are LOV-domain-based blue-light
photoreceptors that control protein degradation by ubiquitination. These proteins were …

Blue light-induced dimerization of a bacterial LOV–HTH DNA-binding protein

BD Zoltowski, LB Motta-Mena, KH Gardner - Biochemistry, 2013 - ACS Publications
With their utilization of light-driven allostery to control biochemical activities, photosensory
proteins are of great interest as model systems and novel reagents for use by the basic …