Chemotherapy is one of the main therapeutic modalities for cancer patients. Cisplatin
(CDDP), as one of the first-line drugs, is of great importance in the chemotherapy of various …

The network of actin filaments is one of the crucial cytoskeletal structures contributing to the
morphological framework of a cell and which participates in the dynamic regulation of …

Paks (p21‐activated kinases) are effectors for the small GTPases Cdc42 (cell division cycle
42) and Rac that play fundamental roles in a wide range of cellular processes, including cell …

WNT/β-catenin signaling is a highly complex pathway that plays diverse roles in various
cellular processes. While WNT ligands usually signal through their dedicated Frizzled …

The p21-activated kinase (PAK) family of serine/threonine kinases is important in
physiological processes including motility, survival, mitosis, transcription and translation …

Abstract P21-activated kinase 1 (PAK1) is associated with colon cancer progression and
metastasis, whereas the molecular mechanism remains elusive. Here, we show that …

The genetic alterations in cancer cells are tightly linked to signaling pathway dysregulation.
Ras is a key molecule that controls several tumorigenesis-related processes, and mutations …

Inactivation of the NF2 tumor suppressor gene has been observed in certain benign and
malignant tumors. Recent studies have demonstrated that merlin, the product of the NF2 …

Purpose This study was conducted to study global gene expression profiles elicited by (−)-
epigallocatechin-3-gallate (EGCG) in mouse liver and small intestine, as well as to identify …

Importance of the field: P21-activated kinases (PAKs) are involved in multiple signal
transduction pathways in mammalian cells. PAKs, and PAK1 in particular, play a role in such …