Multidrug resistance is a leading concern in public health. It describes a complex phenotype
whose predominant feature is resistance to a wide range of structurally unrelated cytotoxic …

Cancer cells frequently display intrinsic or acquired resistance to chemically diverse
anticancer drugs, limiting therapeutic success. Among the main mechanisms of this …

Simple Summary Despite recent therapeutic advances against cancer, many patients do not
respond well or respond poorly, to treatment and develop resistance to more than one anti …

ATP-binding cassette (ABC) transporters mediate the ATP-driven translocation of structurally
and mechanistically distinct substrates against steep concentration gradients. Among the …

The ATP‐binding cassette (ABC) transporter superfamily is one of the largest membrane
protein families existing in wide spectrum of organisms from prokaryotes to human. ABC …

Apoptosis deficiency is one of the most important features observed in neoplastic diseases.
The Bcl-2 family is composed of a subset of proteins that act as decisive apoptosis …

The overexpression of the human ATP-binding cassette (ABC) transporters in cancer cells is
a common mechanism involved in develo** multidrug resistance (MDR). Unfortunately …

Cancer remains a leading cause of morbidity and mortality worldwide. Hence, the increase
in cancer cases observed in the elderly population, as well as in children and adolescents …

Introduction: The overexpression of ATP-binding cassette (ABC) transporters, ABCB1 and
ABCG2, are two of the major mediators of multidrug resistance (MDR) in cancers. Although …

ABCB1 overexpression is known to contribute to multidrug resistance (MDR) in cancers.
Therefore, it is critical to find effective drugs to target ABCB1 and overcome MDR. Erdafitinib …