Cysteine and methionine oxidation in thrombotic disorders
Thrombosis is the leading cause of death in many diseased conditions. Oxidative stress is
characteristic of these conditions. Yet, the mechanisms through which oxidants become …
characteristic of these conditions. Yet, the mechanisms through which oxidants become …
Novel roles of the Nipah virus attachment glycoprotein and its mobility in early and late membrane fusion steps
The Paramyxoviridae family comprises important pathogens that include measles (MeV),
mumps, parainfluenza, and the emerging deadly zoonotic Nipah virus (NiV) and Hendra …
mumps, parainfluenza, and the emerging deadly zoonotic Nipah virus (NiV) and Hendra …
An allosteric redox switch in domain V of β2-glycoprotein I controls membrane binding and anti-domain I autoantibody recognition
β 2-glycoprotein I (β 2 GPI) is an abundant multidomain plasma protein that plays various
roles in the clotting and complement cascades. It is also the main target of antiphospholipid …
roles in the clotting and complement cascades. It is also the main target of antiphospholipid …
Plasmin Cleavage of Beta-2-Glycoprotein I Alters its Structure and Ability to Bind to Pathogenic Antibodies
Abstract Beta-2-Glycoprotein I (β2GPI) is the main autoantigenic target of antiphospholipid
syndrome (APS) with antibodies leading to clinical manifestations. There are two known …
syndrome (APS) with antibodies leading to clinical manifestations. There are two known …
Understanding the Structure of β2-Glycoprotein I: New Insights and Future Paths for Antiphospholipid Syndrome
Antiphospholipid syndrome (APS) is an autoimmune disorder characterized by recurrent life-
threatening blood clots and pregnancy complications in individuals with antiphospholipid …
threatening blood clots and pregnancy complications in individuals with antiphospholipid …